Peng Yichen, Kang Xun, Jiang Bo, Chen Feng, Yang Shoubo, Kang Zhuang, Wang Ce, Lin Yi, Li Shenglan, Han Jiefei, Zhang Botao, Zhang Weichunbai, Li Wenbin
Department of Neuro-oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Front Oncol. 2023 Jan 13;12:1060575. doi: 10.3389/fonc.2022.1060575. eCollection 2022.
Olfactory neuroblastoma is a rare neoplasm that usually presents in the upper nasal cavity. Although its prognosis is highly unfavorable, effective treatment options are still lacking. Moreover, there is no standard treatment for patients with olfactory neuroblastoma that progressed to leptomeningeal carcinomatosis. Here we report an uncommon case of a 59-year-old woman who was diagnosed with olfactory neuroblastoma and leptomeningeal carcinomatosis. For a direct delivery of the drugs to the tumor, and to avoid the impact of lumbar puncture on the patient's quality of life, the intravenous chemotherapy plus intrathecal administration of MTX an Ommaya reservoir was chosen. The results were striking, with the disappearance of tumor cells in the cerebrospinal fluid and the relief of the patient's symptoms with PR. Our result indicates that chemotherapy an Ommaya reservoir offers a new potential therapy for patients with meningeal metastases.
嗅神经母细胞瘤是一种罕见的肿瘤，通常发生在上鼻腔。尽管其预后非常不利，但仍然缺乏有效的治疗选择。此外，对于进展为柔脑膜癌病的嗅神经母细胞瘤患者，尚无标准治疗方法。在此，我们报告一例罕见病例，一名59岁女性被诊断为嗅神经母细胞瘤并伴有柔脑膜癌病。为了将药物直接递送至肿瘤，并避免腰椎穿刺对患者生活质量的影响，选择了静脉化疗加鞘内注射甲氨蝶呤并植入Ommaya储液囊。结果令人瞩目，脑脊液中的肿瘤细胞消失，患者症状缓解，达到部分缓解。我们的结果表明，化疗联合Ommaya储液囊为脑膜转移患者提供了一种新的潜在治疗方法。
