Zheng Hui, Shi Yun-Zhou, Liang Jing-Tao, Lu Liang-Liang, Chen Min
The Third Hospital/Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Neurology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2023 Jan 12;14:1010996. doi: 10.3389/fphar.2023.1010996. eCollection 2023.
To examine the causal effect of potentially modifiable risk factors contributing to migraine pathogenesis. We performed Mendelian randomization analyses and acquired data from United Kingdom Biobank, FinnGen Biobank, and the MRC IEU OpenGWAS data infrastructure. An inverse-variance weighted (IVW) model was used to examine the relationship between 51 potentially modifiable risk factors and migraine in 3215 participants with migraine without aura (MwoA), 3541 participants with migraine with aura (MwA), and 176,107 controls. We adopted a Bonferroni-corrected threshold of = 9.8 × 10-4 (.05 divided by 51 exposures) as a sign of significant effect, and a < .05 was considered as the sign of a suggestive association. More years of schooling significantly correlated with lower odds of MwoA pathogenesis (OR .57 [95%CI .44 to .75], < .0001). More vitamin B12 intake (OR .49 [95%CI .24 to .99], = .046) and lower level of stress [OR 8.17 (95%CI 1.5 to 44.36), = .015] or anxiety disorder (OR 1.92 × 109 [95%CI 8.76 to 4.23*1017], = .029) were suggestive to be correlated lower odds of MwoA pathogenesis. More coffee intake (OR .39 [95%CI .22 to .7], = .001), lower level of eicosapentaenoic acid status (OR 2.54 [95%CI 1.03 to 6.26], = .043), and more light physical activity (OR .09 [95%CI .01 to .94], = .046) were suggestive to be associated with lower odds of MwA. The years of schooling, light physical activity, vitamin B12 intake, and coffee intake were the protective factors for migraine; stress, anxiety, and eicosapentaenoic acid status were harmful factors. Interventions could be developed based on modifying these factors for migraine prophylaxis.
为研究可能可改变的危险因素对偏头痛发病机制的因果影响。我们进行了孟德尔随机化分析，并从英国生物银行、芬兰基因库和医学研究委员会综合流行病学单位开放全基因组关联研究（MRC IEU OpenGWAS）数据基础设施获取数据。采用逆方差加权（IVW）模型，研究3215名无先兆偏头痛（MwoA）患者、3541名有先兆偏头痛（MwA）患者和176,107名对照中51个可能可改变的危险因素与偏头痛之间的关系。我们采用经Bonferroni校正的阈值 = 9.8×10⁻⁴（0.05除以51种暴露因素）作为显著效应的标志，P < 0.05被视为提示性关联的标志。受教育年限增加与MwoA发病几率降低显著相关（比值比[OR]0.57[95%置信区间（CI）0.44至0.75]，P < 0.0001）。维生素B12摄入量增加（OR 0.49[95%CI 0.24至0.99]，P = 0.046）、压力水平降低[OR 8.17（95%CI 1.5至44.36），P = 0.015]或焦虑症（OR 1.92×10⁹[95%CI 8.76至4.23×10¹⁷]，P = 0.029）提示与MwoA发病几率降低相关。咖啡摄入量增加（OR 0.39[95%CI 0.22至0.7]，P = 0.001）、二十碳五烯酸状态水平降低（OR 2.54[95%CI 1.03至6.26]，P = 0.043）以及轻度体力活动增加（OR 0.09[95%CI 0.01至0.94]，P = 0.046）提示与MwA发病几率降低相关。受教育年限、轻度体力活动、维生素B12摄入量和咖啡摄入量是偏头痛的保护因素；压力、焦虑和二十碳五烯酸状态是有害因素。可基于改变这些因素制定干预措施以预防偏头痛。
