哒嗪类化合物领域的研究。第21部分。6-H-嘧啶并[1,2-b]-1,2,4-三唑并哒嗪的结构研究。
Studies in the field of pyridazine compounds. Part 21. Structural studies on 6-H-pyrimido[1,2-b]-1,2,4-triazolopyridazines.
作者信息
Kosary J, Polos K, Kasztreiner E
机构信息
Institute for Drug Research, Budapest, Hungary.
出版信息
Pharmazie. 1987 May;42(5):304-5.
PMID:3671438
Abstract
The structure of 7,8-dihydro-6H-pyrimido [1,2-b]-1,2,4-triazolo [3,4-f] pyridazine (2a) was confirmed by 1H and 13C NMR spectroscopy and by preparation of the isomeric [5,1-f] pyridazine 3. Some derivatives of 6H-pyrimido [1,2-b]-1,2,4,-triazolo [3,4-f]pyridazine were prepared. Compounds 2a, 2b and 9a showed a positive inotropic effect.
摘要
通过1H和13C核磁共振光谱以及制备异构体[5,1-f]哒嗪3，确定了7,8-二氢-6H-嘧啶并[1,2-b]-1,2,4-三唑并[3,4-f]哒嗪（2a）的结构。制备了6H-嘧啶并[1,2-b]-1,2,4-三唑并[3,4-f]哒嗪的一些衍生物。化合物2a、2b和9a表现出正性肌力作用。
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