Koch H P, Mertz M, Zinterhof G
Institut für Pharmazeutische Chemie, Universität Wien, Osterreich.
Pharmazie. 1987 May;42(5):312-5.
In this communication, a report is presented on the drug liberation from so-called floating capsules (with 10 and 15 mg diazepam) and from several other comparable oral and rectal drug dosage forms in the rotating flask model (Resotest-System). None of the commercially available preparations exhibits any availability problem. The rotating flask was suitable and appears as superior over the official dissolution apparatuses with regard to the testing of drug dosage forms that float on the surface of the dissolution medium.
在本交流中，报告了在旋转烧瓶模型（Resotest系统）中，所谓的漂浮胶囊（含10毫克和15毫克地西泮）以及其他几种类似的口服和直肠给药剂型的药物释放情况。市售制剂均未出现任何有效性问题。对于漂浮在溶出介质表面的药物剂型的测试，旋转烧瓶是适用的，并且似乎优于官方溶出装置。
