• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

降低食管闭锁并发症发生率的技术创新,特别关注长期预后:一位外科医生22年的经验

Technical Innovations to Reduce Complication Rates in Esophageal Atresia with Particular Reference to Long-term Outcomes: A Single Surgeon's Experience of 22 Years.

作者信息

Morsi Ahmed, Misra Devesh

机构信息

Department of Paediatric Surgery, The Royal London Hospital, London, England, UK.

出版信息

J Indian Assoc Pediatr Surg. 2022 Nov-Dec;27(6):728-734. doi: 10.4103/jiaps.jiaps_61_22. Epub 2022 Nov 14.

DOI:10.4103/jiaps.jiaps_61_22
PMID:36714494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9878531/
Abstract

BACKGROUND

Following esophageal atresia/tracheoesophageal fistula (EA/TEF) repair, the standard leak rate reported in the literature is 5%-10%, and stricture rate is 40%-72%. There is a global quest for surgical innovations to drive down these complication rates which can cause considerable morbidity.

METHODS

A prospectively maintained database of the senior author's patients who had esophageal atresia repair from 1995 to 2016 was reviewed. Two distinct innovations were implemented: (1) adequate or generous mobilization of the lower esophageal pouch and (2) a 2-5 mm slit in distal esophagus to widen its circumference.

RESULTS

Forty-three patients with EA/TEF were reviewed. Of those, 40 underwent primary repair. The median follow-up was 12.5 years (range 4-26 years). There were no anastomotic leaks and only 8 (20%) patients developed anastomotic strictures requiring dilations (1-5 dilations/patients). One patient (2.5%) had a recurrent fistula. One early mortality was recorded. At the latest follow-up, 35 (87.5%) patients had normal oral feeding, while 1 (2.5%) patient had occasional food sticking episodes. Four syndromic patients (10%) were on jejunal or gastrostomy feeding.

CONCLUSION

An adequate or generous mobilization of the distal esophageal pouch, together with a 2-5 mm slit in the distal esophagus, achieves a tension-free and wide anastomosis. All anastomoses eventually narrow, sometimes just a little, and starting on a higher scale with a small slit, helps. These seemingly minor innovations, when used together, contributed to a substantially lower complication rate sustained over a 22-year period - no leaks and only 20% stricture rate.

摘要

背景

食管闭锁/食管气管瘘(EA/TEF)修复术后,文献报道的标准漏率为5%-10%,狭窄率为40%-72%。全球都在寻求手术创新以降低这些可导致相当高发病率的并发症发生率。

方法

回顾了资深作者前瞻性维护的1995年至2016年接受食管闭锁修复患者的数据库。实施了两项不同的创新措施:(1)充分或广泛游离食管下段囊袋;(2)在食管远端做一个2-5毫米的切口以扩大其周长。

结果

对43例EA/TEF患者进行了回顾。其中,40例接受了一期修复。中位随访时间为12.5年(范围4-26年)。无吻合口漏,仅8例(20%)患者发生吻合口狭窄需要扩张(每位患者1-5次扩张)。1例患者(2.5%)出现复发性瘘。记录到1例早期死亡。在最近一次随访时,35例(87.5%)患者经口进食正常,而1例(2.5%)患者偶尔有食物黏附情况。4例综合征患者(10%)通过空肠或胃造口喂养。

结论

充分或广泛游离食管远端囊袋,同时在食管远端做一个2-5毫米的切口,可实现无张力且宽大的吻合。所有吻合口最终都会变窄,有时只是轻微变窄,从较大尺度开始并做一个小切口会有帮助。这些看似微小的创新措施一起使用时,在22年期间使并发症发生率大幅降低——无漏且狭窄率仅为20%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6b/9878531/f2f0058e3a15/JIAPS-27-728-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6b/9878531/f2f0058e3a15/JIAPS-27-728-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6b/9878531/f2f0058e3a15/JIAPS-27-728-g001.jpg

相似文献

1
Technical Innovations to Reduce Complication Rates in Esophageal Atresia with Particular Reference to Long-term Outcomes: A Single Surgeon's Experience of 22 Years.降低食管闭锁并发症发生率的技术创新,特别关注长期预后:一位外科医生22年的经验
J Indian Assoc Pediatr Surg. 2022 Nov-Dec;27(6):728-734. doi: 10.4103/jiaps.jiaps_61_22. Epub 2022 Nov 14.
2
Challenging surgical dogma in the management of proximal esophageal atresia with distal tracheoesophageal fistula: Outcomes from the Midwest Pediatric Surgery Consortium.挑战近端食管闭锁合并远端气管食管瘘治疗中的外科教条:来自中西部儿科外科联盟的结果
J Pediatr Surg. 2018 Jul;53(7):1267-1272. doi: 10.1016/j.jpedsurg.2017.05.024. Epub 2017 Jun 1.
3
Categorization and repair of recurrent and acquired tracheoesophageal fistulae occurring after esophageal atresia repair.食管闭锁修复术后复发性及后天性气管食管瘘的分类与修复
J Pediatr Surg. 2017 Mar;52(3):424-430. doi: 10.1016/j.jpedsurg.2016.08.012. Epub 2016 Aug 31.
4
Revisional surgery for recurrent tracheoesophageal fistula and anastomotic complications after repair of esophageal atresia in 258 infants.258例食管闭锁修复术后复发性气管食管瘘及吻合口并发症的翻修手术
J Pediatr Surg. 2015 Feb;50(2):250-4. doi: 10.1016/j.jpedsurg.2014.11.004. Epub 2014 Nov 7.
5
Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula.食管闭锁及食管气管瘘的围手术期管理与预后
J Pediatr Surg. 2017 Aug;52(8):1245-1251. doi: 10.1016/j.jpedsurg.2016.11.046. Epub 2016 Dec 5.
6
Modified method of primary esophageal anastomosis with improved outcome in cases of esophageal atresia with tracheoesophageal fistula.改良的原发性食管吻合术方法改善了食管闭锁合并气管食管瘘病例的治疗效果。
Pediatr Surg Int. 2009 Apr;25(4):369-72. doi: 10.1007/s00383-009-2337-7. Epub 2009 Feb 12.
7
Prediction and prevention of anastomotic complications of esophageal atresia and tracheoesophageal fistula.食管闭锁及食管气管瘘吻合口并发症的预测与预防
J Pediatr Surg. 1990 Jul;25(7):778-81. doi: 10.1016/s0022-3468(05)80018-1.
8
Infants with esophageal atresia and right aortic arch: Characteristics and outcomes from the Midwest Pediatric Surgery Consortium.患有食管闭锁和右位主动脉弓的婴儿:来自中西部儿科外科学会的特征与结果
J Pediatr Surg. 2019 Apr;54(4):688-692. doi: 10.1016/j.jpedsurg.2018.08.002. Epub 2018 Aug 21.
9
Proposal of a novel method to evaluate anastomotic tension in esophageal atresia with a distal tracheoesophageal fistula.一种评估合并远端气管食管瘘的食管闭锁中吻合口张力的新方法的提议。
Pediatr Surg Int. 2005 Oct;21(10):780-5. doi: 10.1007/s00383-005-1540-4. Epub 2005 Oct 21.
10
Correction of esophageal atresia with distal tracheoesophageal fistula.食管闭锁合并远端气管食管瘘的矫治
J Thorac Cardiovasc Surg. 1983 Feb;85(2):229-36.

本文引用的文献

1
Recommendations for endoscopic surveillance after esophageal atresia repair in adults.成人食管闭锁修复术后内镜监测的建议。
Dis Esophagus. 2022 Jul 12;35(7). doi: 10.1093/dote/doab095.
2
Thoracoscopic oesophageal atresia/tracheo-oesophageal fistula (OA/TOF) repair is associated with a higher stricture rate: a single institution's experience.胸腔镜食管闭锁/气管食管瘘(OA/TOF)修复术与更高的狭窄率相关:单机构经验。
Pediatr Surg Int. 2021 Mar;37(3):397-401. doi: 10.1007/s00383-020-04829-3. Epub 2021 Feb 7.
3
Clinical outcomes following implementation of a management bundle for esophageal atresia with distal tracheoesophageal fistula.
实施食管闭锁伴远端气管食管瘘管理套餐后的临床结果。
J Pediatr Surg. 2021 Jan;56(1):47-54. doi: 10.1016/j.jpedsurg.2020.09.049. Epub 2020 Oct 6.
4
The burden of esophageal dilatations following repair of esophageal atresia.食管闭锁修复术后食管扩张的负担。
J Pediatr Surg. 2020 Nov;55(11):2329-2334. doi: 10.1016/j.jpedsurg.2020.02.018. Epub 2020 Feb 19.
5
ERNICA Consensus Conference on the Management of Patients with Esophageal Atresia and Tracheoesophageal Fistula: Follow-up and Framework.《食管闭锁和食管气管瘘患者管理的 ERNICA 共识会议:随访和框架》
Eur J Pediatr Surg. 2020 Dec;30(6):475-482. doi: 10.1055/s-0039-3400284. Epub 2019 Nov 27.
6
Oesophageal atresia.食管闭锁。
Nat Rev Dis Primers. 2019 Apr 18;5(1):26. doi: 10.1038/s41572-019-0077-0.
7
Postoperative noninvasive ventilation and complications in esophageal atresia-tracheoesophageal fistula.食管闭锁-气管食管瘘术后的无创通气与并发症
J Pediatr Surg. 2019 May;54(5):945-948. doi: 10.1016/j.jpedsurg.2019.01.023. Epub 2019 Jan 31.
8
Anastomotic Strictures after Esophageal Atresia Repair: Timing of Dilatation during the First Two Postoperative Years.食管闭锁修复术后吻合口狭窄:术后头两年内扩张的时机
Surg J (N Y). 2018 May 7;4(2):e62-e65. doi: 10.1055/s-0038-1646950. eCollection 2018 Apr.
9
Four cancer cases after esophageal atresia repair: Time to start screening the upper gastrointestinal tract.4 例食管闭锁修复术后癌症病例:开始筛查上消化道的时机到了。
World J Gastroenterol. 2018 Mar 7;24(9):1056-1062. doi: 10.3748/wjg.v24.i9.1056.
10
Utilizing stricture indices to predict dilation of strictures after esophageal atresia repair.利用狭窄指数预测食管闭锁修复术后狭窄的扩张情况。
J Surg Res. 2017 Aug;216:172-178. doi: 10.1016/j.jss.2017.04.024. Epub 2017 May 10.