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降低食管闭锁并发症发生率的技术创新,特别关注长期预后:一位外科医生22年的经验

Technical Innovations to Reduce Complication Rates in Esophageal Atresia with Particular Reference to Long-term Outcomes: A Single Surgeon's Experience of 22 Years.

作者信息

Morsi Ahmed, Misra Devesh

机构信息

Department of Paediatric Surgery, The Royal London Hospital, London, England, UK.

出版信息

J Indian Assoc Pediatr Surg. 2022 Nov-Dec;27(6):728-734. doi: 10.4103/jiaps.jiaps_61_22. Epub 2022 Nov 14.

Abstract

BACKGROUND

Following esophageal atresia/tracheoesophageal fistula (EA/TEF) repair, the standard leak rate reported in the literature is 5%-10%, and stricture rate is 40%-72%. There is a global quest for surgical innovations to drive down these complication rates which can cause considerable morbidity.

METHODS

A prospectively maintained database of the senior author's patients who had esophageal atresia repair from 1995 to 2016 was reviewed. Two distinct innovations were implemented: (1) adequate or generous mobilization of the lower esophageal pouch and (2) a 2-5 mm slit in distal esophagus to widen its circumference.

RESULTS

Forty-three patients with EA/TEF were reviewed. Of those, 40 underwent primary repair. The median follow-up was 12.5 years (range 4-26 years). There were no anastomotic leaks and only 8 (20%) patients developed anastomotic strictures requiring dilations (1-5 dilations/patients). One patient (2.5%) had a recurrent fistula. One early mortality was recorded. At the latest follow-up, 35 (87.5%) patients had normal oral feeding, while 1 (2.5%) patient had occasional food sticking episodes. Four syndromic patients (10%) were on jejunal or gastrostomy feeding.

CONCLUSION

An adequate or generous mobilization of the distal esophageal pouch, together with a 2-5 mm slit in the distal esophagus, achieves a tension-free and wide anastomosis. All anastomoses eventually narrow, sometimes just a little, and starting on a higher scale with a small slit, helps. These seemingly minor innovations, when used together, contributed to a substantially lower complication rate sustained over a 22-year period - no leaks and only 20% stricture rate.

摘要

背景

食管闭锁/食管气管瘘(EA/TEF)修复术后,文献报道的标准漏率为5%-10%,狭窄率为40%-72%。全球都在寻求手术创新以降低这些可导致相当高发病率的并发症发生率。

方法

回顾了资深作者前瞻性维护的1995年至2016年接受食管闭锁修复患者的数据库。实施了两项不同的创新措施:(1)充分或广泛游离食管下段囊袋;(2)在食管远端做一个2-5毫米的切口以扩大其周长。

结果

对43例EA/TEF患者进行了回顾。其中,40例接受了一期修复。中位随访时间为12.5年(范围4-26年)。无吻合口漏,仅8例(20%)患者发生吻合口狭窄需要扩张(每位患者1-5次扩张)。1例患者(2.5%)出现复发性瘘。记录到1例早期死亡。在最近一次随访时,35例(87.5%)患者经口进食正常,而1例(2.5%)患者偶尔有食物黏附情况。4例综合征患者(10%)通过空肠或胃造口喂养。

结论

充分或广泛游离食管远端囊袋,同时在食管远端做一个2-5毫米的切口,可实现无张力且宽大的吻合。所有吻合口最终都会变窄,有时只是轻微变窄,从较大尺度开始并做一个小切口会有帮助。这些看似微小的创新措施一起使用时,在22年期间使并发症发生率大幅降低——无漏且狭窄率仅为20%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d6b/9878531/f2f0058e3a15/JIAPS-27-728-g001.jpg

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