普萘洛尔和胰高血糖素对安替比林和水杨酸钠药代动力学的影响。
The influence of propranolol and glucagon on the pharmacokinetics of antipyrine and sodium salicylate.
作者信息
Orszulak-Michalak D, Kaszubski P
机构信息
Department of Pharmacodynamics, Medical Academy, Lodź, Poland.
出版信息
Pharmazie. 1987 Jun;42(6):394-6.
Propranolol (1) decreases hepatic blood flow and glucagon (2) exerts an opposite effect on hepatic circulation. The effects of these drugs on the pharmacokinetics of phenazone (3; antipyrine)-a compound with low coefficient of hepatic extraction, and sodium salicylate (4) that is highly extracted by liver, were studied on rabbits. It was shown that changes in the pharmacokinetics of 3 and 4 in the presence of 1 or 2, seemed to be interactions between these drugs in the haemodynamic phase.
普萘洛尔（1）会减少肝血流量，而胰高血糖素（2）对肝循环有相反的作用。研究了这些药物对非那宗（3；安替比林）——一种肝提取系数较低的化合物，以及肝对其有高度提取作用的水杨酸钠（4）的药代动力学的影响，实验对象为兔子。结果表明，在存在1或2的情况下，3和4药代动力学的变化似乎是这些药物在血流动力学阶段的相互作用。
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