[Pharmacokinetic characteristics of drug substance in liver denervation].

In experiments on male rats the pharmacokinetics of antipyrine, hexenal and phenylbutazone was studied 7 days after the liver denervation produced by subdiaphragmatic vagotomy, sympathotomy and their combination. It was found that in all variants of the liver denervation there occurs an increase of the period of half-life and a decrease of clearance of the drugs. As the liver denervation practically does not change the degree of protein binding and the hepatic blood flow velocity, it is thought that suppression of the drug biotransformation in hepatocytes due to suppression of the activity of enzymes of their microsomal oxidative system underlies changes in the pharmacokinetics of drugs.