Diaz Palarea M D, Gonzalez M C, Rodriguez M
Department of Physiology, School of Medicine, La Laguna University, Tenerife, Canary Islands, Spain.
Physiol Behav. 1987;40(6):785-9. doi: 10.1016/0031-9384(87)90284-8.
Recently we have reported a marked rat lateralization in the T-maze choice. The present study examines the relationship between the ascending monoaminergic systems and the T-maze behavioral asymmetry. There were no significant differences for serotonin or norepinephrine between the T-maze preferred and non-preferred brain sides in the s. nigra, ventral tegmental area, striatum, acumbens, frontal lobe or hippocampus. Only in the hippocampus was dopamine concentration significantly greater for the brain site ipsilateral to the T-maze choice side. Previously, we reported that both apomorphine, a dopamine receptor agonist, and 6-hydroxydopamine lesion in the medial forebrain bundle of the catecholaminergic neurons affect the T-maze asymmetry; we therefore suggested that the T-maze choice could be related with the ascending dopaminergic systems. The present data strongly support this hypothesis and suggest that the DA cells involved in the spatial asymmetry in the T-maze are included in the dopaminergic mesohippocampal system.
最近我们报道了大鼠在T迷宫选择中存在明显的偏侧化现象。本研究探讨了上行单胺能系统与T迷宫行为不对称之间的关系。在黑质、腹侧被盖区、纹状体、伏隔核、额叶或海马中，T迷宫偏好侧和非偏好侧脑区的血清素或去甲肾上腺素水平没有显著差异。仅在海马中，与T迷宫选择侧同侧的脑区多巴胺浓度显著更高。此前，我们报道多巴胺受体激动剂阿扑吗啡以及儿茶酚胺能神经元内侧前脑束中的6-羟基多巴胺损伤都会影响T迷宫的不对称性；因此我们认为T迷宫选择可能与上行多巴胺能系统有关。目前的数据有力地支持了这一假设，并表明参与T迷宫空间不对称的多巴胺能细胞包含在多巴胺能中脑-海马系统中。
