Roberts Jill M, Fraser Justin F
Departments of Neurosurgery and Neuroscience, University of Kentucky, Lexington, KY, USA.
Methods Mol Biol. 2023;2616:47-54. doi: 10.1007/978-1-0716-2926-0_6.
Moyamoya is a cerebrovascular condition that predisposes affected patients to stroke and is characterized as the progressive stenosis of the internal carotid artery (ICA) and compensatory development of collaterals at the base of the brain. Patients with moyamoya syndrome also present with comorbidities such as various autoimmune diseases and coagulopathies. We developed a surgical method using micro-coils to induce ICA-specific stenosis in mice, which induces moyamoya-like vasculopathies. An advantage of this surgical model of hypoperfusion is that it can be combined with other comorbid models to investigate pathologies associated with moyamoya syndrome.
烟雾病是一种脑血管疾病，使受影响的患者易患中风，其特征是颈内动脉（ICA）进行性狭窄以及脑底部侧支循环的代偿性发育。烟雾病综合征患者还伴有各种自身免疫性疾病和凝血障碍等合并症。我们开发了一种使用微线圈在小鼠中诱导ICA特异性狭窄的手术方法，该方法可诱发类似烟雾病的血管病变。这种低灌注手术模型的一个优点是它可以与其他合并症模型相结合，以研究与烟雾病综合征相关的病理情况。
