Department of Ophthalmology, Nigde Omer Halis Demir University Training and Research Hospital, Nigde, Turkey.
Department of Ophthalmology, Dr. Behçet Uz Training and Research Hospital, Ege University, Izmir, Turkey.
Optom Vis Sci. 2023 Mar 1;100(3):207-210. doi: 10.1097/OPX.0000000000001996. Epub 2023 Jan 30.
Mechanical factors are also associated with meibomian gland dysregulation in patients with pterygium. Dry eye parameters were assessed, and the results support the association between pterygium and dry eye disease.
This study aimed to investigate how meibomian gland dysfunction and dry eye parameters relate to the existence of pterygium.
Patients with pterygium and healthy volunteers of similar age and demographic characteristics were included. Schirmer 1 test, Ocular Surface Disease Index score, fluorescein tear film breakup time, and ocular surface staining scores (Oxford score) were recorded. Meiboscores were estimated based on meibomian gland loss rate on infrared meibography (SL-D701; Topcon, IJssel, the Netherlands). The symmetry of meibomian gland loss with respect to eyelid midline was assessed.
Fifty-four eyes with pterygium (group 1) and 50 eyes of healthy volunteers (group 2) were included. The mean ages were 54.0 ± 12.3 and 52.3 ± 8.0 years, respectively. Schirmer 1 test results and tear film breakup time were lower in group 1 ( P = .007, P < .001). Oxford and Ocular Surface Disease Index scores were significantly higher in group 1 ( P = .009, P < .001). The mean meiboscores were significantly higher in group 1 ( P < .001). There was meibomian gland depletion in 90.7% (49 of 54) of group 1 and 32% (16 of 50) of group 2 ( P < .001). Meibomian gland loss region was distributed asymmetrically in 75.5% (37 of 49) of the eyes in group 1, but not in any of the eyes in group 2. The asymmetry was located on the side where the pterygium was detected in 94.5% (35 of 37) of these eyes.
Meibomian glands are influenced morphologically and functionally in eyes with pterygium. The overlap of the pterygium location and meibomian gland abnormality suggests a direct mechanical relationship. In managing pterygium patients, the possibility of meibomian gland dysfunction and associated evaporative dry eye should be considered.
机械因素也与翼状胬肉患者的睑板腺功能障碍有关。评估干眼参数，结果支持翼状胬肉与干眼病之间的关联。
本研究旨在探讨睑板腺功能障碍和干眼参数与翼状胬肉的存在有何关系。
纳入翼状胬肉患者和年龄及人口统计学特征相似的健康志愿者。记录 Schirmer 1 试验、眼表疾病指数评分、泪膜破裂时间和眼表面染色评分（Oxford 评分）。根据红外睑板腺照相（SL-D701；Topcon，IJssel，荷兰）得出的睑板腺丢失率来估计睑板腺评分。评估睑板腺丢失相对于睑缘中线的对称性。
纳入 54 只翼状胬肉眼（第 1 组）和 50 只健康志愿者眼（第 2 组）。平均年龄分别为 54.0±12.3 岁和 52.3±8.0 岁。第 1 组的 Schirmer 1 试验结果和泪膜破裂时间较低（P=0.007，P<0.001）。第 1 组的 Oxford 和眼表疾病指数评分显著较高（P=0.009，P<0.001）。第 1 组的平均睑板腺评分显著较高（P<0.001）。第 1 组中有 90.7%（49/54）的眼存在睑板腺缺失，而第 2 组中仅有 32%（16/50）的眼存在（P<0.001）。第 1 组中 75.5%（37/49）的眼的睑板腺缺失区域分布不对称，但第 2 组中没有任何眼的分布不对称。这些眼中的 94.5%（35/37）的眼，睑板腺异常的位置与翼状胬肉的位置重叠。
翼状胬肉眼的睑板腺在形态和功能上受到影响。翼状胬肉位置和睑板腺异常的重叠表明存在直接的机械关系。在管理翼状胬肉患者时，应考虑到睑板腺功能障碍和相关蒸发性干眼症的可能性。
