Corley Elizabeth A, Pace Erika, Barnacle Alex M, Patel Premal A, Thway Khin, Chisholm Julia C
Paediatric and Adolescent Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital and Institute of Cancer Research, Sutton.
Department of Diagnostic Radiology, The Royal Marsden Hospital.
J Pediatr Hematol Oncol. 2023 Mar 1;45(2):e279-e284. doi: 10.1097/MPH.0000000000002612. Epub 2023 Jan 16.
Angiomatoid fibrous histiocytoma (AFH) is a soft tissue neoplasm of intermediate biological potential. Typically a slow-growing tumor, it can recur locally. Rarely, it manifests as a soft tissue sarcoma capable of metastasis. When metastases are nonamenable to local therapy, it is believed uniformly fatal. We present 3 patients with metastatic AFH who demonstrated a sustained response to chemotherapy; including one who achieved complete remission with cryoablation. These cases reinforce the potential value of chemotherapy in some patients with unresectable metastatic AFH and provide the first case in the literature of cryoablation in AFH.
血管样纤维组织细胞瘤（AFH）是一种具有中等生物学潜能的软组织肿瘤。通常生长缓慢，可局部复发。罕见情况下，它表现为具有转移能力的软组织肉瘤。当转移灶无法进行局部治疗时，通常认为是致命的。我们报告了3例转移性AFH患者，他们对化疗表现出持续反应；其中1例通过冷冻消融实现了完全缓解。这些病例强化了化疗在一些无法切除的转移性AFH患者中的潜在价值，并提供了文献中首例AFH冷冻消融的病例。
