Singh Lachhman, Ranjan Nihar
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, New Transit Campus, Lucknow 226002, Uttar Pradesh, India.
J Am Chem Soc. 2023 Feb 8;145(5):2745-2749. doi: 10.1021/jacs.2c10850. Epub 2023 Jan 30.
Nitrite (NO) is a physiologically significant anion having implications for cellular signaling. Here we report our serendipitous discovery of highly selective fluorescence-based nitrite sensing using a benzimidazole which stems from hitherto-unknown direct nitration of a benzimidazole using sodium nitrite. Using one- and two-dimensional NMR techniques, we elucidate the chemical structures of the new nitrated benzimidazoles and show differences in the nitration products using conventional nitration with nitric acid. We also show its utility in robust sensing of nitrite-containing samples.
亚硝酸盐（NO）是一种对细胞信号传导有重要影响的生理活性阴离子。在此，我们报告了一项意外发现，即使用苯并咪唑实现基于荧光的高选择性亚硝酸盐传感，这源于亚硝酸钠对苯并咪唑进行的前所未知的直接硝化反应。利用一维和二维核磁共振技术，我们阐明了新硝化苯并咪唑的化学结构，并展示了与用硝酸进行常规硝化反应所得硝化产物的差异。我们还展示了其在对含亚硝酸盐样品进行可靠传感方面的实用性。
