1990 年至 2021 年期间韩国釜山 HIV 感染者癌症发病率和种类的变化趋势。

Changing trends in the incidence and spectrum of cancers between 1990 and 2021 among HIV-infected patients in Busan, Korea.

机构信息

Division of Infectious Disease, Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea.

出版信息

J Infect Chemother. 2023 Jun;29(6):571-575. doi: 10.1016/j.jiac.2023.01.018. Epub 2023 Jan 27.

DOI:10.1016/j.jiac.2023.01.018

PMID:36716862

Abstract

BACKGROUND

Long-term follow-up data on cancer incidence and spectrum among human immunodeficiency virus (HIV)-infected individuals in Korea have been scarce.

MATERIAL AND METHODS

This retrospective cohort study included HIV-infected individuals visiting a tertiary care hospital in Busan, South Korea between 1990 and 2021. The observation was divided into 4 periods. The incidence rate was calculated using direct standardization on age and sex, stratified by calendar period.

RESULTS

Of the 1,297 patients, 92 patients (7.1%) were diagnosed with 97 cancers. Excluding 37 patients with prevalent cancer, 1,260 patients were followed for a total of 8,803.7 person-years (PYs), and 55 patients developed 60 incident cancers including 5 second primary incident cancers. In men, the AIDS-defining cancer (ADC) incidence decreased from 294.7 per 100,000 PYs in 1990-1997 to 124.8 per 100,000 PYs in 2014-2021, while the non-AIDS-defining cancer (NADC) incidence increased from 0 per 100,000 PYs to 316.5 per 100,000 PYs during the same period. The proportion of virus-unrelated NADCs (VU-NADCs) increased from 33.3% in 1998-2005 to 49% in 2014-2021. The proportion of human papillomavirus-associated cancers (HPVACs) has recently increased in both ADCs and NADCs. The median time from HIV diagnosis to their first cancer was 1.48 years for ADCs, 6.11 years for VR-NADCs, 8.3 years for VU-NADCs, and 11.5 years for HPVACs.

CONCLUSION

The incidence of NADCs is increasing with the aging of HIV-infected patients, and thus, it is necessary to promote cancer screening and prevention programs.

摘要

背景

在韩国，关于艾滋病毒（HIV）感染者癌症发病率和类型的长期随访数据很少。

材料和方法

这项回顾性队列研究纳入了 1990 年至 2021 年期间在韩国釜山一家三级保健医院就诊的 HIV 感染者。观察分为 4 个时期。按年龄和性别进行直接标准化，按日历时期分层计算发病率。

结果

在 1297 名患者中，92 名（7.1%）患者被诊断出患有 97 种癌症。排除 37 名患有现患癌症的患者后，1260 名患者共随访了 8803.7 人年（PY），其中 55 名患者发生了 60 例新发癌症，包括 5 例第二原发新发癌症。在男性中，艾滋病定义性癌症（ADC）的发病率从 1990-1997 年的每 100000 人年 294.7 例降至 2014-2021 年的每 100000 人年 124.8 例，而非艾滋病定义性癌症（NADC）的发病率从同期的每 100000 人年 0 例升至 316.5 例。与病毒无关的 NADCs（VU-NADCs）的比例从 1998-2005 年的 33.3%增加到 2014-2021 年的 49%。人乳头瘤病毒相关性癌症（HPVACs）在 ADC 和 NADCs 中的比例最近都有所增加。从 HIV 诊断到首次癌症的中位时间为 ADCs 的 1.48 年，VR-NADCs 的 6.11 年，VU-NADCs 的 8.3 年和 HPVACs 的 11.5 年。