Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Zhengzhou Tobacco Institute of China National Tobacco Company, Zhengzhou 450001, China.
Ageing Res Rev. 2023 Apr;86:101865. doi: 10.1016/j.arr.2023.101865. Epub 2023 Jan 27.
Alzheimer's disease (AD) is the commonest neurodegenerative disease with slow progression. Pieces of evidence suggest that the GABAergic system is impaired in the early stage of AD, leading to hippocampal neuron over-activity and further leading to memory and cognitive impairment in patients with AD. However, the precise impairment mechanism of the GABAergic system on the pathogenesis of AD is still unclear. The impairment of neural networks associated with the GABAergic system is tightly associated with AD. Therefore, we describe the roles played by hippocampus-related GABAergic circuits and their impairments in AD neuropathology. In addition, we give our understand on the process from GABAergic circuit impairment to cognitive and memory impairment, since recent studies on astrocyte in AD plays an important role behind cognition dysfunction caused by GABAergic circuit impairment, which helps better understand the GABAergic system and could open up innovative AD therapy.
阿尔茨海默病（AD）是最常见的神经退行性疾病，其进展缓慢。有证据表明，AD 早期的 GABA 能系统受损，导致海马神经元过度活跃，进而导致 AD 患者的记忆和认知障碍。然而，GABA 能系统对 AD 发病机制的确切损害机制尚不清楚。与 GABA 能系统相关的神经网络的损伤与 AD 密切相关。因此，我们描述了与海马相关的 GABA 能回路及其在 AD 神经病理学中的损伤所起的作用。此外，我们还阐述了从 GABA 能回路损伤到认知和记忆损伤的过程，因为最近关于 AD 中星形胶质细胞的研究在 GABA 能回路损伤引起的认知功能障碍背后起着重要作用，这有助于更好地了解 GABA 能系统，并为 AD 治疗开辟新途径。
