雄激素剥夺治疗的老年前列腺癌男性与认知功能相关的运动。
Exercise Associated with Cognitive Function in Older Men with Prostate Cancer Undergoing Androgen Deprivation Therapy.
机构信息
Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.
出版信息
Int J Behav Med. 2023 Dec;30(6):924-929. doi: 10.1007/s12529-022-10150-1. Epub 2023 Jan 30.
BACKGROUND
To examine associations between exercise and cognitive function in older men undergoing hormone therapy for prostate cancer.
METHOD
Men ≥ 65 years old with prostate cancer, currently undergoing androgen deprivation therapy for ≥ 6 months (n = 50), completed the Godin-Shephard Leisure-Time Physical Activity Questionnaire, and standard neuropsychological tests. Pearson's correlations and linear regressions were used to examine associations between exercise and cognitive performance.
RESULTS
Exercise was significantly positively correlated with performance on tests of memory, attention, and executive function. Linear regressions showed that when controlling for age and education, exercise remained a significant predictor of attention and executive function performance (p < 0.05), and showed moderate, but statistically non-significant effects on memory performance (p < 0.10).
CONCLUSION
Greater exercise is associated with better functioning in multiple cognitive domains in men with prostate cancer undergoing hormone therapy, providing proof-of-concept evidence that exercise may be a feasible intervention to limit cognitive dysfunction in prostate cancer patients.
背景
研究雄激素剥夺治疗前列腺癌的老年男性中运动与认知功能的相关性。
方法
年龄≥65 岁、患有前列腺癌、正在接受雄激素剥夺治疗≥6 个月的男性（n=50）完成了 Godin-Shephard 休闲时间体育活动问卷和标准神经心理学测试。采用 Pearson 相关分析和线性回归分析来检验运动与认知表现之间的相关性。
结果
运动与记忆力、注意力和执行功能测试的表现呈显著正相关。线性回归表明，当控制年龄和教育程度时，运动仍然是注意力和执行功能表现的显著预测因素（p<0.05），并且对记忆表现有适度但统计学上无显著性的影响（p<0.10）。
结论
雄激素剥夺治疗前列腺癌的男性中，运动与多个认知领域的功能更好相关，这为运动可能是限制前列腺癌患者认知功能障碍的可行干预措施提供了初步证据。
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