Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.
Russian Clinical Research Center for Gerontology, Ministry of Healthcare of the Russian Federation, Pirogov Russian National Research Medical University, Moscow, 129226, Russia.
Biochemistry (Mosc). 2022 Dec;87(12):1465-1476. doi: 10.1134/S0006297922120045.
For a long time Nrf2 transcription factor has been attracting attention of researchers investigating phenomenon of aging. Numerous studies have investigated effects of Nrf2 on aging and cell senescence. Nrf2 is often considered as a key player in aging processes, however this needs to be proven. It should be noted that most studies were carried out on invertebrate model organisms, such as nematodes and fruit flies, but not on mammals. This paper briefly presents main mechanisms of mammalian aging and role of inflammation and oxidative stress in this process. The mechanisms of Nrf2 activity regulation, its involvement in aging and development of the senescence-associated secretory phenotype (SASP) are also discussed. Main part of this review is devoted to critical analysis of available experimental data on the role of Nrf2 in mammalian aging.
长期以来，Nrf2 转录因子一直吸引着研究衰老现象的研究人员的关注。许多研究已经调查了 Nrf2 对衰老和细胞衰老的影响。Nrf2 通常被认为是衰老过程中的关键参与者，但这需要证明。值得注意的是，大多数研究都是在无脊椎动物模式生物（如线虫和果蝇）上进行的，而不是在哺乳动物上进行的。本文简要介绍了哺乳动物衰老的主要机制以及炎症和氧化应激在这一过程中的作用。还讨论了 Nrf2 活性调节的机制、它在衰老和衰老相关分泌表型（SASP）的发展中的作用。本综述的主要部分致力于对 Nrf2 在哺乳动物衰老中的作用的现有实验数据进行批判性分析。
