先天免疫与病态细胞死亡。
Innate Immunity and Phenoptosis.
机构信息
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.
Russian Clinical Research Center for Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, Moscow, 129226, Russia.
出版信息
Biochemistry (Mosc). 2022 Dec;87(12):1634-1639. doi: 10.1134/S0006297922120185.
The hypothesis is proposed that activation of innate immunity is the primary mechanism of phenoptosis (programmed death of an organism). In support of the hypothesis, we discuss (i) the data on active release of signaling molecules from the cell producing excessive inflammation; (ii) the data on contribution of mitochondrial production of reactive oxygen species to immune response.
该假说提出，先天免疫的激活是细胞发生细胞凋亡（机体程序性死亡）的主要机制。为支持该假说，我们讨论了（i）关于产生过度炎症的细胞中信号分子的主动释放的相关数据；（ii）关于线粒体产生的活性氧物质对免疫反应的贡献的相关数据。
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