The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Department of Newborn Care Center, Senior Department of Pediatrics, The Seventh Medical Center of PLA General Hospital, Beijing, China.
Pediatr Pulmonol. 2023 May;58(5):1417-1426. doi: 10.1002/ppul.26336. Epub 2023 Feb 8.
To describe the status of coronavirus disease 2019 (COVID-19) vaccination with inactivated vaccines BBIBP-CorV and CoronaVac in Chinese children aged 3-7 years with bronchopulmonary dysplasia (BPD), and explore factors influencing vaccination and reasons for nonvaccination.
This cross-sectional study involving parents of 397 BPD children aged 3-7 years was conducted through WeChat or follow-up telephone interviews using a standardized questionnaire form. Factors influencing COVID-19 vaccination were explored by using modified Poisson regression models.
The overall COVID-19 vaccination rate was 69.0% (95% confidence interval: 64.3%-73.4%). COVID-19 vaccination was less likely to be accepted in children whose mothers had a relatively high educational background (university and above), who lived in urban areas and had a low birth weight (<1 kg), a history of hospitalization for lung diseases in the past 12 months, and intellectual disability. Conversely, kindergarten students and children from families with an annual income of >300,000 CNY ( 41,400 USD) were more likely to accept vaccination. Adverse reactions occurred in 13/274 children (4.7%) within 10 days after vaccination. With respect to reasons of not accepting COVID-19 vaccination, 95 parents (77.2%) worried about the adverse reactions, and 17 parents (13.8%) refused vaccination on the excuse of not being convenient to go to the vaccination station or not knowing where to get the vaccines.
The COVID-19 vaccination rate in BPD children aged 3-7 years needs to be further improved in China. Continuous efforts are required to monitor postvaccination adverse reactions in BPD children, and make vaccination more convenient and accessible.
描述中国 3-7 岁患有支气管肺发育不良（BPD）的儿童中使用灭活疫苗 BBIBP-CorV 和科兴疫苗进行 2019 年冠状病毒病（COVID-19）疫苗接种的现状，并探讨影响接种的因素和未接种的原因。
通过微信或随访电话访谈，使用标准化问卷形式对 397 名 3-7 岁 BPD 儿童的家长进行了这项横断面研究。采用修正泊松回归模型探讨 COVID-19 疫苗接种的影响因素。
COVID-19 疫苗接种的总体接种率为 69.0%（95%置信区间：64.3%-73.4%）。在母亲具有较高教育背景（大学及以上）、居住在城市地区且出生体重较低（<1kg）、过去 12 个月有肺部疾病住院史和智力残疾的儿童中，COVID-19 疫苗接种的接受程度较低。相反，幼儿园学生和家庭年收入超过 30 万元（41400 美元）的儿童更有可能接受接种。274 名儿童中有 13 名（4.7%）在接种后 10 天内发生不良反应。对于不接受 COVID-19 疫苗接种的原因，95 名家长（77.2%）担心不良反应，17 名家长（13.8%）以去接种点不方便或不知道在哪里获得疫苗为由拒绝接种。
中国 3-7 岁 BPD 儿童的 COVID-19 疫苗接种率有待进一步提高。需要持续努力监测 BPD 儿童接种后的不良反应，并使接种更加方便和普及。
