新生儿阿片类戒断综合征母婴对子中药物治疗与出生时住院利用之间的关系。
Association between pharmacologic treatment and hospital utilization at birth among neonatal opioid withdrawal syndrome mother-infant dyads.
机构信息
Program for Patient Safety and Quality, Boston Children's Hospital, Boston, MA, USA.
Office of Health Equity and Inclusion, Boston Children's Hospital, Boston, MA, USA.
出版信息
J Perinatol. 2023 Mar;43(3):283-292. doi: 10.1038/s41372-023-01623-6. Epub 2023 Jan 30.
OBJECTIVE
We linked mother-baby dyads to explore associations between maternal medication-assisted therapy (MAT) and infants' pharmacologic treatment on birth hospital utilization for infants with NOWS.
METHODS
We extracted singleton infant and maternal delivery discharges from PHIS hospitals with large volumes of deliveries for 2016-2019. We matched newborns with NOWS to maternal delivery discharges by hospital, day of birth, mode of delivery, and ZIP code. We examined the association between maternal MAT, infants' pharmacologic treatment, and hospital utilization at birth.
RESULTS
We included N = 146 mother-baby dyads from six hospitals (74% match rate). Among matched dyads, 51% received maternal MAT, 60% pharmacotherapy (37% both). Infants treated non-pharmacologically and born to mothers receiving MAT had the shortest stays vs. infants without pharmacotherapy or MAT (RR = 0.29; 95% CI: 0.25-0.35).
CONCLUSIONS
These findings underscore the importance of adequate perinatal treatment for opioid use disorder to improve outcomes for mothers and infants with opioid exposure.
目的
我们将母婴对子联系起来，以探索产妇药物辅助治疗（MAT）与婴儿出生时药物治疗之间的关联，这些婴儿患有新生儿戒断综合征（NOWS）。
方法
我们从 2016 年至 2019 年有大量分娩量的 PHIS 医院中提取了单胎婴儿和产妇分娩出院记录。我们通过医院、出生日、分娩方式和邮政编码将有 NOWS 的新生儿与产妇分娩出院记录相匹配。我们检查了产妇 MAT、婴儿药物治疗和出生时医院利用之间的关联。
结果
我们纳入了来自六家医院的 146 对母婴对子（匹配率为 74%）。在匹配的母婴对子中，51%接受了产妇 MAT，60%接受了药物治疗（37%两者兼有）。与未接受药物治疗或 MAT 的婴儿相比，接受非药物治疗且母亲接受 MAT 的婴儿住院时间最短（RR=0.29；95%CI：0.25-0.35）。
结论
这些发现强调了充分的围产期治疗对阿片类药物使用障碍的重要性，以改善有阿片类药物暴露的母亲和婴儿的结局。
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