一种核苷酸衍生物庚胺醇 AMP 酰胺（HAA）在小鼠和自发性高血压大鼠（SHR）中的免疫增强活性。

Immunopotentiating activity of a nucleotide derivative, heptaminol AMP amidate (HAA) in mice and spontaneously hypertensive rats (SHR).

作者信息

Saha A R, Ueno K, Mitsuhashi H, Ohmori S, Igarashi T, Kitagawa H

机构信息

Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University, Japan.

出版信息

Res Commun Chem Pathol Pharmacol. 1987 Jul;57(1):117-27.

PMID:3671874

Abstract

The immunopotentiating activity of heptaminol AMP amidate (HAA), a new derivative of 5'-AMP, was examined in experimental animals. Anti-SRBC PFC activity and antibody titer values augmented for both of single and 4 days consecutive administrations in ICR male mice. The dose of 10 mg/kg was found to cause the maximum enhancement. In spontaneously hypertensive rats, with a state of immunosuppression, 10 days consecutive administrations of HAA at the dose of 10 mg/kg was found to increase significantly the anti-SRBC PFC and antibody titer values. From these results, it is tempting to suggest that HAA may possess an immunopotentiating activity.

摘要

对5'-AMP的新衍生物庚胺醇AMP酰胺（HAA）的免疫增强活性在实验动物中进行了研究。在ICR雄性小鼠中，单次和连续4天给药后，抗SRBC PFC活性和抗体滴度值均有所增加。发现10mg/kg的剂量可引起最大增强。在处于免疫抑制状态的自发性高血压大鼠中，连续10天给予10mg/kg剂量的HAA可显著提高抗SRBC PFC和抗体滴度值。从这些结果来看，很容易推测HAA可能具有免疫增强活性。