布瑞马佐辛对不同大小大鼠排尿的影响。
Bremazocine-induced urination in rats of different sizes.
作者信息
Leander J D
机构信息
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285.
出版信息
Res Commun Chem Pathol Pharmacol. 1987 Jul;57(1):141-4.
PMID:3671877
Abstract
The increased urine output after injection of the kappa agonist bremazocine was determined in rats of various body weights. Rats of all sizes were sensitive to the diuretic effect of bremazocine. The total diuretic effect was greater in heavier animals. The urine output plateaued between 4-5 ml/100 g body weight irrespective of body weight at the higher doses of bremazocine.
摘要
在不同体重的大鼠中测定了注射κ受体激动剂布瑞马佐辛后的尿量增加情况。所有大小的大鼠对布瑞马佐辛的利尿作用均敏感。较重动物的总利尿作用更大。在较高剂量的布瑞马佐辛作用下，无论体重如何，尿量在4 - 5毫升/100克体重之间趋于平稳。
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