Sumikawa K, Hayashi Y, Fukumitsu K, Yoshiya I
Department of Anesthesiology, Toyonaka Municipal Hospital, Osaka, Japan.
Res Commun Chem Pathol Pharmacol. 1987 Jul;57(1):45-53.
Effects of dantrolene sodium on catecholamine (CA) release from the perfused dog adrenal medulla was investigated in relation to it's therapeutic action on malignant hyperthermia (MH), in which CAs would play a significant pathophysiological role. Acetylcholine (ACh)-induced CA release was not affected, whereas caffeine-induced CA release was inhibited by dantrolene in a dose-dependent manner (84% inhibition at 10 microM). Dantrolene had no effect on the CA release induced by lasalocid or Na+ deprivation. On the other hand halothane inhibited ACh-induced CA release markedly, Na+ deprivation-induced CA release slightly, but not caffeine-induced CA release at all. The results indicate that dantrolene selectively inhibit caffeine-induced CA release, and that the therapeutic action of dantrolene on MH would be, at least in part, due to inhibition of abnormal release of Ca2+ in the adrenal medullary cells.
研究了丹曲林钠对灌注犬肾上腺髓质儿茶酚胺（CA）释放的影响，并将其与丹曲林钠对恶性高热（MH）的治疗作用相关联，在恶性高热中儿茶酚胺发挥着重要的病理生理作用。乙酰胆碱（ACh）诱导的CA释放不受影响，而咖啡因诱导的CA释放受到丹曲林的剂量依赖性抑制（在10 microM时抑制率为84%）。丹曲林对拉沙洛西或钠缺乏诱导的CA释放没有影响。另一方面，氟烷显著抑制ACh诱导的CA释放，轻度抑制钠缺乏诱导的CA释放，但对咖啡因诱导的CA释放完全没有影响。结果表明，丹曲林选择性抑制咖啡因诱导的CA释放，并且丹曲林对恶性高热的治疗作用至少部分归因于抑制肾上腺髓质细胞中异常的钙释放。
