由快速生长分枝杆菌引起的皮肤和软组织感染。
Skin and soft tissue infections due to rapidly growing mycobacteria.
作者信息
Sepulcri Chiara, Vena Antonio, Bassetti Matteo
机构信息
Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genova.
IRCCS Ospedale Policlinico San Martino, Genova, Italy.
出版信息
Curr Opin Infect Dis. 2023 Apr 1;36(2):74-80. doi: 10.1097/QCO.0000000000000905. Epub 2023 Jan 30.
PURPOSE OF REVIEW
The aim of this article is to review skin and soft tissue infections due to rapidly growing mycobacteria (RGM), with a particular focus on recently published literature (2021-2022).
RECENT FINDINGS
RGM are increasingly reported as a cause of skin and soft tissue infections, both in the community setting and as a cause of nosocomial outbreaks. Recent advances in molecular methods have expanded the number of species of RGM and resulted in increased diagnosis. New treatment options are under evaluation particularly for Mycobacterium abscessus , the most difficult-to-treat among RGM.
SUMMARY
RGM are an uncommon cause of skin and soft tissue infections and a high clinical suspicion together with advanced laboratory facilities are required for diagnosis. Species identification and antimicrobial susceptibility testing are essential to drive appropriate treatment, which combines surgical debridement with prolonged antimycobacterial combination therapy.
综述目的
本文旨在综述快速生长分枝杆菌（RGM）引起的皮肤和软组织感染，特别关注最近发表的文献（2021 - 2022年）。
最新发现
RGM作为皮肤和软组织感染的病因越来越多地被报道，在社区环境以及医院感染暴发中均有出现。分子方法的最新进展增加了RGM的种类数量并提高了诊断率。新的治疗方案正在评估中，尤其是针对脓肿分枝杆菌，它是RGM中最难治疗的菌种。
总结
RGM是皮肤和软组织感染的罕见病因，诊断需要高度的临床怀疑以及先进的实验室设施。菌种鉴定和抗菌药敏试验对于推动适当的治疗至关重要，治疗方法是手术清创与延长的抗分枝杆菌联合治疗相结合。
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