Zhao Ting, Shen Hao, Zhang Hui-Lan, Feng Jie, Liu Si-Ming, Wang Ting-Ting, Li Hong-Jian, Yu Lu-Hai
Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Province, 830001, China.
Institute of Clinical Pharmacy of Xinjiang Uygur Autonomous Region, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Province, 830001, China.
Pharmacogenomics. 2023 Feb;24(3):141-151. doi: 10.2217/pgs-2022-0159. Epub 2023 Jan 31.
To evaluate the association between , and polymorphisms and voriconazole plasma concentrations in Uygur pediatric patients with allogeneic hematopoietic stem cell transplantation. High performance liquid chromatography-mass spectrometry was employed to monitor voriconazole concentrations. First-generation sequencing was performed to detect gene polymorphisms. Voriconazole concentrations of normal metabolizers were significantly higher than those of intermediate (p < 0.05) and ultrafast (p < 0.001) metabolizers. Patients with GG and GA genotypes exhibited significantly lower voriconazole concentrations compared with patients with the AA genotype (p < 0.05). These results demonstrate a significant association between voriconazole concentrations and the phenotype in Uygur pediatric patients with allogeneic hematopoietic stem cell transplantation.
评估维吾尔族儿童异基因造血干细胞移植患者中 、 和 基因多态性与伏立康唑血药浓度之间的关联。采用高效液相色谱 - 质谱联用技术监测伏立康唑浓度。进行一代测序以检测基因多态性。正常代谢者的伏立康唑浓度显著高于中间代谢者（p < 0.05）和超快代谢者（p < 0.001）。与AA基因型患者相比，GG和GA基因型患者的伏立康唑浓度显著降低（p < 0.05）。这些结果表明，在维吾尔族儿童异基因造血干细胞移植患者中，伏立康唑浓度与 表型之间存在显著关联。
