Cognitive Rhythms Collaborative, Boston University, Boston, United States.
Department of Mathematics and Statistics, Boston University, Rochester, United States.
Elife. 2023 Jan 31;12:e67684. doi: 10.7554/eLife.67684.
Even during sustained attention, enhanced processing of attended stimuli waxes and wanes rhythmically, with periods of enhanced and relatively diminished visual processing (and subsequent target detection) alternating at 4 or 8 Hz in a sustained visual attention task. These alternating attentional states occur alongside alternating dynamical states, in which lateral intraparietal cortex (LIP), the frontal eye field (FEF), and the mediodorsal pulvinar (mdPul) exhibit different activity and functional connectivity at α, β, and γ frequencies-rhythms associated with visual processing, working memory, and motor suppression. To assess whether and how these multiple interacting rhythms contribute to periodicity in attention, we propose a detailed computational model of FEF and LIP. When driven by θ-rhythmic inputs simulating experimentally-observed mdPul activity, this model reproduced the rhythmic dynamics and behavioral consequences of observed attentional states, revealing that the frequencies and mechanisms of the observed rhythms allow for peak sensitivity in visual target detection while maintaining functional flexibility.
即使在持续关注期间，注意力集中的刺激处理也会有节奏地增强和减弱，在持续的视觉注意力任务中，以 4 或 8 Hz 的频率交替出现增强和相对减弱的视觉处理（和随后的目标检测）时期。这些交替的注意状态伴随着交替的动力学状态，在这些状态中，顶内旁小叶 (LIP)、额眼区 (FEF) 和中脑背盖 (mdPul) 在 α、β 和 γ 频率下表现出不同的活动和功能连接——与视觉处理、工作记忆和运动抑制相关的节律。为了评估这些相互作用的多个节律是否以及如何导致注意力的周期性，我们提出了一个 FEF 和 LIP 的详细计算模型。当由模拟实验观察到的 mdPul 活动的θ节律输入驱动时，该模型再现了观察到的注意状态的节律动力学和行为后果，表明观察到的节律的频率和机制允许在保持功能灵活性的同时提高视觉目标检测的灵敏度。
