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本文引用的文献

1
Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial.模型指导下的重症患者β-内酰胺类抗生素和环丙沙星的精准给药：一项多中心随机临床试验。
Intensive Care Med. 2022 Dec;48(12):1760-1771. doi: 10.1007/s00134-022-06921-9. Epub 2022 Nov 9.
2
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial.基于治疗药物监测的哌拉西林/他唑巴坦剂量优化对脓毒症相关器官功能障碍的影响：一项随机对照试验。
Intensive Care Med. 2022 Mar;48(3):311-321. doi: 10.1007/s00134-021-06609-6. Epub 2022 Feb 1.
3
From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotics.从治疗药物监测到抗生素模型指导下的精准给药。
Clin Pharmacol Ther. 2021 Apr;109(4):928-941. doi: 10.1002/cpt.2202. Epub 2021 Mar 16.
4
Population pharmacokinetics of four β-lactams in critically ill septic patients comedicated with amikacin.重症脓毒症患者合用阿米卡星时四种β-内酰胺类药物的群体药代动力学。
Clin Biochem. 2012 Jul;45(10-11):780-6. doi: 10.1016/j.clinbiochem.2012.03.030. Epub 2012 Apr 5.
5
Population pharmacokinetic analysis and dosing regimen optimization of meropenem in adult patients.美罗培南在成年患者中的群体药代动力学分析及给药方案优化
J Clin Pharmacol. 2006 Oct;46(10):1171-8. doi: 10.1177/0091270006291035.

Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter.

作者信息

Liebchen Uwe, Briegel Josef, Brinkmann Alexander, Frey Otto, Wicha Sebastian G

机构信息

Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.

Department of Anaesthesiology and Intensive Care Medicine, General Hospital of Heidenheim, Heidenheim, Germany.

出版信息

Intensive Care Med. 2023 Apr;49(4):475-476. doi: 10.1007/s00134-023-06990-4. Epub 2023 Jan 31.

DOI:10.1007/s00134-023-06990-4
PMID:36719458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10119245/
Abstract
摘要