Tourtellotte W W, Schmid P, Shapshak P
Neurology and Research Services, VAMC West Los Angeles, Wadsworth Division, California 90073.
Riv Neurol. 1987 May-Jun;57(3):163-5.
A progress report. We have helped to standardize an advanced in situ hybridization technology to detect viral nucleic sequences in formalin fixed paraffin embedded brain tissue with high sensitivity and specificity as well as good preservation of cytomorphology. It is our belief that if the inflammation in the multiple sclerosis central nervous system is associated with persistent virus this technique should reveal it. Technical reasons are given why we are continuing to search for measles virus in multiple sclerosis brain tissue.
一份进展报告。我们已助力将一项先进的原位杂交技术标准化，该技术能以高灵敏度、高特异性以及良好的细胞形态保存效果，检测福尔马林固定石蜡包埋脑组织中的病毒核酸序列。我们认为，如果多发性硬化症中枢神经系统中的炎症与持续性病毒有关，这项技术应该能够揭示这一点。报告给出了我们继续在多发性硬化症脑组织中寻找麻疹病毒的技术原因。
