Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
ICES, Toronto, Ontario, Canada.
Diabetes Care. 2023 Apr 1;46(4):751-756. doi: 10.2337/dc22-1936.
Cardiovascular risk reduction is an important focus in the management of people with diabetes. Although event rates have been declining over the long term, they have been observed to plateau or reverse in recent years. Furthermore, the impact of income-related disparities in cardiovascular events is unknown. The objective of this study is to evaluate age-, sex-, and income-related trends in cardiovascular hospitalization rates among people with diagnosed diabetes.
We calculated rates of hospitalization for acute myocardial infarction, stroke, heart failure, and lower-extremity amputation in annual cohorts of the entire population of Ontario, Canada, with diagnosed diabetes, from 1995 to 2019. Event rates were stratified by age, sex, and income level.
We studied nearly 1.7 million people with diabetes. The rate of acute myocardial infarction declined throughout the 25-year study period (P < 0.0001), such that the rate in 2019 was less than half the rate in 1995. Rates of stroke (P < 0.0001), heart failure (P < 0.0001), and amputation (P < 0.0001) also changed over time, but hospitalization rates stabilized through the 2010s. This apparent stabilization concealed a growing income-related disparity: wealthier patients showed continued declines in rates of these outcomes during the decade, whereas rates for lower-income patients increased (P for interaction < 0.0001 for all four outcomes).
During a quarter-century of follow-up, cardiovascular hospitalization rates among people with diabetes fell. However, the apparent stabilization in rates of stroke, heart failure, and amputation in recent years masks the fact that rates have risen for lower-income individuals.
降低心血管风险是管理糖尿病患者的一个重要关注点。尽管长期以来事件发生率一直在下降,但近年来观察到其趋于平稳或出现逆转。此外,尚不清楚心血管事件与收入相关差异的影响。本研究旨在评估有明确诊断的糖尿病患者心血管住院率的年龄、性别和收入相关趋势。
我们计算了 1995 年至 2019 年期间,加拿大安大略省所有有明确诊断的糖尿病患者的年度队列中因急性心肌梗死、中风、心力衰竭和下肢截肢而住院的比率。按年龄、性别和收入水平对事件率进行分层。
我们研究了近 170 万患有糖尿病的患者。在 25 年的研究期间,急性心肌梗死的发生率一直在下降(P < 0.0001),以至于 2019 年的发生率不到 1995 年的一半。中风(P < 0.0001)、心力衰竭(P < 0.0001)和截肢(P < 0.0001)的发生率也随时间发生变化,但住院率在 2010 年代趋于稳定。这种表面的稳定掩盖了一个不断扩大的与收入相关的差距:较富裕的患者在这十年中这些结果的发生率继续下降,而低收入患者的发生率却在上升(所有四种结果的交互 P 值均 < 0.0001)。
在 25 年的随访期间,糖尿病患者的心血管住院率下降。然而,近年来中风、心力衰竭和截肢的发生率趋于稳定,掩盖了低收入人群的发病率上升的事实。