[伴有中心滤泡细胞的恶性淋巴瘤与假骨髓瘤性溶骨性骨病变相关]
[Malignant lymphoma with centrofollicular cells associated with pseudomyelomatous lytic bone lesions].
作者信息
Thyss A, Hoffman P, Michiels J F, Thyss-Puyraimond F, Lupera H, Schneider M
机构信息
Service d'Hématologie-Oncologie, Centre Antoine-Lacassagne, Nice.
出版信息
Rev Rhum Mal Osteoartic. 1987 Jul-Sep;54(7-9):601-3.
The authors report on 3 cases of malignant lymphoma associated with well-defined lytic lesions of the skull and limbs that were identical to lesions observed in patients with multiple myeloma. In two patients, subcutaneous nodules were found opposite the site of bone lysis. Histologic examination diagnosed centrofollicular cell malignant lymphoma in all 3 cases. The exceptional nature of such lesions in patients with malignant lymphoma is discussed in connection with literature data. The suggested physiopathologic mechanism is secretion of an "osteoclast activation factor" (OAF) by malignant lymphoid B cells.
作者报告了3例恶性淋巴瘤病例，这些病例伴有颅骨和四肢明确的溶骨性病变，与多发性骨髓瘤患者所观察到的病变相同。在两名患者中，在骨溶解部位的对侧发现了皮下结节。组织学检查在所有3例病例中均诊断为中心滤泡细胞恶性淋巴瘤。结合文献数据讨论了恶性淋巴瘤患者此类病变的特殊性质。推测的病理生理机制是恶性B淋巴细胞分泌“破骨细胞激活因子”（OAF）。
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