在乳制品生产过程中，要警惕高毒力的肺炎克雷伯氏菌 K1、K2、K3、K5、K54 和 K57 菌株。
Keeping alert to the hypervirulent K1, K2, K3, K5, K54 and K57 strains of Klebsiella pneumoniae within dairy production process.
机构信息
MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; Key Lab of Animal Bacteriology, Ministry of Agriculture, Nanjing 210095, China; OIE Reference Lab for Swine Streptococcosis, Nanjing 210095, China.
出版信息
Microbes Infect. 2023 Jun;25(5):105106. doi: 10.1016/j.micinf.2023.105106. Epub 2023 Jan 28.
Klebsiella pneumoniae (Kp) is now recognized as an urgent threat to public health since the emergence of multidrug-resistant and hypervirulent isolates. We identified a hypervirulent K2 isolate from the milk samples possibly associated with an infection incident in children, which raised the alarm to the zoonotic potential of bovine mastitis Kp as a foodborne pathogen. Subsequently, numerous K1, K2, K3, K5, K54 and K57 strains were identified from mastitis milk samples, and showed high pathogenicity in infected mouse. Further analysis based on complete genomes found that these isolates showed closely evolutionary relationships with the human hypervirulent strains in diverse phylogenetic lineages, suggesting their potential risk to public health.
肺炎克雷伯菌（Kp）现在被认为是对公众健康的一个紧迫威胁，因为出现了多药耐药和高毒力的分离株。我们从牛奶样本中鉴定出一种高毒力的 K2 分离株，可能与儿童感染事件有关，这引起了人们对牛乳腺炎克雷伯菌作为食源性病原体的人畜共患病潜力的警惕。随后，从乳腺炎牛奶样本中鉴定出许多 K1、K2、K3、K5、K54 和 K57 株，在感染的小鼠中显示出很高的致病性。基于全基因组的进一步分析发现，这些分离株与不同进化谱系中的人类高毒力株具有密切的进化关系，表明它们对公众健康存在潜在风险。
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