Medical Psychology and Medical Sociology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Department of Psychosomatic Medicine und Psychotherapy, University Hospital Bonn, Bonn, Germany; Department of Psychosomatic Medicine and Psychotherapy, University Hospital Muenster, Muenster, Germany.
J Affect Disord. 2023 Apr 1;326:132-138. doi: 10.1016/j.jad.2023.01.091. Epub 2023 Jan 28.
A generalized proinflammatory state has been observed in individuals with panic disorder (PD). There is evidence that slow-paced breathing (SPB) with heart rate variability-biofeedback (HRV-BF) strengthens the nervus vagus with its anti-inflammatory pathway. Therefore, with this randomized controlled trial we aimed to investigate the effect of a four-week SPB with HRV-BF intervention on pro-inflammatory cytokines in people with PD. Fifty-five individuals with PD (mean age: 37.22 ± 15.13 years) were randomly allocated either to SPB-HRV-BF (intervention group) or to HRV-Sham-BF (active control group). SPB-HRV-BF was performed over four weeks while cytokine concentration and HRV during a short-term resting condition were measured before and after intervention. SPB-HRV-BF decreased concentration of Tumor Necrosis Factor alpha (TNF-alpha) (F = 4.396, p ≤ .05, η2 = 0.077) in individuals with PD. In addition, SPB-HRV-BF demonstrated an increase in the HRV-time and frequency domain parameters SDNN, Total Power and LF during short-term resting condition. There was no intervention effect in HRV-Sham-BF group. In conclusion, SBP-HRV-BF as a non-pharmacological treatment may reduce pro-inflammatory cytokine TNF-alpha via the cholinergic anti-inflammatory pathway in individuals with PD. Based on the generalized proinflammatory state in PD, decreasing TNF-alpha is highly beneficial to reduce risk of cardiovascular diseases and metabolic syndrome.
已在惊恐障碍（PD）患者中观察到普遍的促炎状态。有证据表明，慢节奏呼吸（SPB）与心率变异性生物反馈（HRV-BF）通过抗炎途径增强迷走神经。因此，我们旨在通过这项随机对照试验，调查为期四周的 SPB 与 HRV-BF 干预对 PD 患者促炎细胞因子的影响。55 名 PD 患者（平均年龄：37.22±15.13 岁）被随机分配到 SPB-HRV-BF（干预组）或 HRV-Sham-BF（主动对照组）。在四周的时间内进行 SPB-HRV-BF，同时在干预前后测量短期静息状态下细胞因子浓度和 HRV。SPB-HRV-BF 降低了 PD 患者肿瘤坏死因子-α（TNF-α）的浓度（F=4.396，p≤.05，η2=0.077）。此外，SPB-HRV-BF 在短期静息条件下显示出 HRV 时间和频域参数 SDNN、总功率和 LF 的增加。HRV-Sham-BF 组没有干预效果。总之，作为一种非药物治疗，SPB-HRV-BF 可能通过胆碱能抗炎途径降低 PD 患者的促炎细胞因子 TNF-α。基于 PD 中的普遍促炎状态，降低 TNF-α 非常有利于降低心血管疾病和代谢综合征的风险。
