Sipponen P, Järvi O, Kekki M, Siurala M
Dept. of Pathology, Jorvi Hospital, Espoo, Finland.
Scand J Gastroenterol. 1987 Sep;22(7):865-71. doi: 10.3109/00365528708991927.
The incidence of gastric carcinoma (GCA) has decreased throughout the world. This decrease is attributed to a decline in incidence of the intestinal type of GCA (IGCA), whereas the diffuse (DGCA) type of GCA is considered to be endemic in nature and more stable in incidence. In the present study we have estimated how much the incidences of IGCA and DGCA have decreased in percentage in Finland from 1952-61 to 1972-81. Our calculations are based on the Finnish Cancer Registry data of new GCA cases, on population statistics in Finland, and on the percentage distribution of GCA subtypes in three consecutive samples of GCA patients collected in the time periods 1952-61 (reference series) and 1972-81 (two separate samples: series A and B). The samples totaled 1837 GCA cases. We calculated that the incidence of IGCA had decreased from 1952-61 to 1972-81 by 62-71% (reference series versus series A - reference series versus series B) among men and by 69-70% among women. Correspondingly, the incidence of DGCA was calculated to have decreased by 30-39% among men and 37-42% among women. We conclude that not only has the incidence of IGCA decreased in percentage approximately twice as much as the incidence of DGCA but DGCA has also distinctly decreased in incidence in Finland from 1952-61 to 1972-81.
全球范围内，胃癌（GCA）的发病率呈下降趋势。这种下降归因于肠型胃癌（IGCA）发病率的降低，而弥漫型胃癌（DGCA）在本质上被认为是地方性的，发病率更为稳定。在本研究中，我们估算了1952 - 1961年至1972 - 1981年期间芬兰IGCA和DGCA的发病率下降了多少百分比。我们的计算基于芬兰癌症登记处新GCA病例的数据、芬兰的人口统计数据，以及在1952 - 1961年（参考系列）和1972 - 1981年（两个独立样本：系列A和系列B）期间收集的连续三个GCA患者样本中GCA亚型的百分比分布。样本总数为1837例GCA病例。我们计算得出，1952 - 1961年至1972 - 1981年期间，男性中IGCA的发病率下降了62 - 71%（参考系列与系列A - 参考系列与系列B），女性中下降了69 - 70%。相应地，男性中DGCA的发病率计算得出下降了30 - 39%，女性中下降了37 - 42%。我们得出结论，不仅IGCA的发病率下降百分比大约是DGCA发病率下降百分比的两倍，而且从1952 - 1961年至1972 - 1981年期间，芬兰DGCA的发病率也明显下降。
