Orthopedics, Hamamatsu Red Cross Hospital, Hamamatsu, Shizuoka, Japan.
Orthopedic Oncology, Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan.
BMJ Case Rep. 2023 Jan 31;16(1):e250218. doi: 10.1136/bcr-2022-250218.
The standard treatment for extraskeletal myxoid chondrosarcoma is wide excision. However, extraskeletal myxoid chondrosarcoma is often located in the deep layers of the extremities and pelvis, so functional impairment due to wide resection is unavoidable in many cases. In addition, the efficacy of radiotherapy and chemotherapy has not been defined, so no treatment method is established for unresectable cases. Here we report a case involving a man in his late 60s with extraskeletal myxoid chondrosarcoma of the pelvis who responded to proton beam radiotherapy with intra-arterial chemotherapy and did not require surgery. The patient maintained a complete response for more than 7 years. The findings from this case suggest that definitive irradiation can be an alternative to wide resection for cases of extraskeletal myxoid chondrosarcoma in which severe disability cannot be avoided after resection or when the tumour is inoperable due to its size and location.
骨外黏液样软骨肉瘤的标准治疗方法是广泛切除。然而，骨外黏液样软骨肉瘤常位于四肢和骨盆的深部，因此在许多情况下，广泛切除不可避免地会导致功能损伤。此外，放疗和化疗的疗效尚未确定，因此对于不可切除的病例尚无治疗方法。在这里，我们报告了 1 例 60 多岁的男性骨盆部骨外黏液样软骨肉瘤患者，该患者接受质子束放疗联合动脉内化疗后无需手术，且完全缓解超过 7 年。该病例提示，对于因切除后严重残疾不可避免，或因肿瘤大小和位置无法手术的骨外黏液样软骨肉瘤病例，根治性放疗可替代广泛切除。
