高级别浆液性卵巢癌患者中输卵管上皮内浆液性癌（STIC）的频率。

Frequency of serous tubal intraepithelial carcinoma (STIC) in patients with high grade serous ovarian cancer.

机构信息

Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, College of Medicine, South Korea; Paik Institute for Clinical Research, Inje University, College of Medicine, South Korea.

Department of Pathology, Inje University, College of Medicine, South Korea.

出版信息

Taiwan J Obstet Gynecol. 2023 Jan;62(1):107-111. doi: 10.1016/j.tjog.2022.09.006.

DOI:10.1016/j.tjog.2022.09.006

PMID:36720520

Abstract

OBJECTIVE

Serous tubal intraepithelial carcinoma (STIC) is a known precursor of high-grade serous ovarian cancer (HGSOC). This study aimed to evaluate the proportion of STIC in patients with HGSOC and analyze the STIC-related prognosis in patients with HGSOC.

MATERIALS AND METHODS

All pathology reports at our institution that included bilateral salpingectomies of patients with HGSOC from January 2013 to December 2018 were reviewed by two experienced pathologists. The specimens from the ovaries and the salpinx including fimbria were examined. We analyzed the correlation between STIC and HGSOC and compared the clinical characteristics and STIC-related prognostic outcomes in patients with HGSOC.

RESULTS

Eleven of the 76 cases were STIC. BRCA mutations were found in 16.9% of patients with HGSOC. STIC was observed in 30.0% of patients with BRCA mutations and in 14.3% of patients without BRCA mutations. The incidence of STIC in patients with BRCA mutations was approximately twice that in patients without BRCA mutations; however, the difference was not statistically significant (P = 0.231). Further, the 5-year survival rate of patients without STIC appeared to be high; nevertheless, the difference was not statistically significant (59.7% vs. 47.4%, P = 0.633). Moreover, there was no significant difference in disease-free survival rate according to STIC (36.4% vs. 33.1%, P = 0.956).

CONCLUSION

STIC was identified in patients with HGSOC, and STIC incidence was prominent in HGSOC related to BRCA mutation. Although low frequency, STIC was detected in patients without BRCA mutation. Therefore, prophylactic salpingectomy may be useful for prevention of HGSOC.

摘要

目的

输卵管上皮内癌（STIC）是高级别浆液性卵巢癌（HGSOC）的已知前体。本研究旨在评估 HGSOC 患者中 STIC 的比例，并分析 HGSOC 患者中与 STIC 相关的预后。

材料与方法

对本机构 2013 年 1 月至 2018 年 12 月间所有 HGSOC 患者的双侧输卵管切除术的病理报告进行了回顾性分析，由两位经验丰富的病理学家进行评估。检查卵巢和输卵管标本，包括伞端。我们分析了 STIC 与 HGSOC 的相关性，并比较了 HGSOC 患者的临床特征和与 STIC 相关的预后结果。

结果

76 例患者中有 11 例为 STIC。HGSOC 患者中发现 BRCA 突变的占 16.9%。BRCA 突变患者中 STIC 的发生率为 30.0%，无 BRCA 突变患者中为 14.3%。BRCA 突变患者中 STIC 的发生率约为无 BRCA 突变患者的两倍，但差异无统计学意义（P=0.231）。此外，无 STIC 的患者 5 年生存率似乎较高，但差异无统计学意义（59.7%比 47.4%，P=0.633）。此外，根据 STIC 情况，无病生存率无显著差异（36.4%比 33.1%，P=0.956）。