R. D. Berlin Center for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Department of Dermatology, University of Utah, Salt Lake City, Utah, USA.
Pediatr Dermatol. 2023 Jul-Aug;40(4):698-701. doi: 10.1111/pde.15251. Epub 2023 Jan 31.
Subcorneal pustular dermatosis (SPD) and annular pustular psoriasis (APP) are very rare in childhood and difficult to differentiate both clinically and histopathologically. We report the case of a 10-year-old male with a 9-year history of erythematous scaly annular plaques with scattered pustules on the trunk. Although initially diagnosed as SPD, a lack of response to dapsone, presence of spongiosis on histology, and early age of disease onset led to consideration of APP. The patient was subsequently treated with adalimumab 80 mg weekly and completely cleared. This case illustrates the overlapping features of SPD and APP and suggests that the two disorders may represent a spectrum of the same disease.
棘层下脓疱性皮病（SPD）和环状脓疱性银屑病（APP）在儿童中非常罕见，且在临床和组织病理学上均难以区分。我们报告了一例 10 岁男性，其病史长达 9 年，表现为躯干红斑性鳞屑性环状斑块，伴有散在脓疱。尽管最初诊断为 SPD，但由于对氨苯砜治疗无反应、组织学上存在海绵形成以及疾病发病年龄较早，考虑 APP 的可能性。随后，该患者接受阿达木单抗 80mg 每周一次治疗，皮损完全消退。该病例说明了 SPD 和 APP 的重叠特征，并提示这两种疾病可能代表同一疾病的不同表现。
