Department of Translational Medicine, Clinical Research Centre, Skaone University Hospital, Lund University, Malmo SE-20213, Sweden.
Department of Biotechnology, Indian Institute of Technology IIT, Chennai, India.
Brief Funct Genomics. 2024 Jan 18;23(1):69-74. doi: 10.1093/bfgp/elad001.
The entire world is facing the stiff challenge of COVID-19 pandemic. To overcome the spread of this highly infectious disease, several short-sighted strategies were adopted such as the use of broad-spectrum antibiotics and antifungals. However, the misuse and/or overuse of antibiotics have accentuated the emergence of the next pandemic: antimicrobial resistance (AMR). It is believed that pathogens while transferring between humans and the environment carry virulence and antibiotic-resistant factors from varied species. It is presumed that all such genetic factors are quantifiable and predictable, a better understanding of which could be a limiting step for the progression of AMR. Herein, we have reviewed how genomics-based understanding of host-pathogen interactions during COVID-19 could reduce the non-judicial use of antibiotics and prevent the eruption of an AMR-based pandemic in future.
全球正面临着 COVID-19 大流行的严峻挑战。为了遏制这种高度传染性疾病的传播，人们采取了一些目光短浅的策略，例如使用广谱抗生素和抗真菌药物。然而，抗生素的滥用和/或过度使用加剧了下一次大流行的出现：抗微生物药物耐药性（AMR）。据信，病原体在人与人之间以及人与环境之间转移时，会从不同物种携带毒力和抗生素耐药性因素。人们推测，所有这些遗传因素都是可以量化和预测的，如果能更好地理解这些因素，就可能成为控制 AMR 发展的一个限制步骤。在此，我们回顾了 COVID-19 期间基于基因组学的宿主-病原体相互作用的理解如何减少非司法使用抗生素，并防止未来基于 AMR 的大流行的爆发。
