Department of Anaesthesiology and Perioperative Medicine and Department of Intensive Care Unit, Xijing Hospital, The Fourth Military Medical University, 710032 Xi'an, Shaanxi, China.
College of Life Sciences, Northwest University, 710069 Xi'an, Shaanxi, China.
J Integr Neurosci. 2023 Jan 16;22(1):19. doi: 10.31083/j.jin2201019.
Ferroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain injury, and sepsis-associated encephalopathy. This review summarizes the pathogenesis of ferroptosis and its relationship with various nervous system disorders.
铁死亡是一种有别于其他细胞程序性死亡形式的新型死亡方式，其特征是铁的积累和脂质过氧化。铁通过芬顿反应与氧发生作用在氧化脂质的过程中起着关键作用。因此，铁的积累会导致磷脂过氧化，从而引发铁死亡。此外，谷胱甘肽的解毒作用在铁死亡过程中被破坏。越来越多的研究表明，铁死亡与神经系统疾病如抑郁症、神经退行性疾病、中风、创伤性脑损伤和脓毒症相关脑病有关。本综述总结了铁死亡的发病机制及其与各种神经系统疾病的关系。
