A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A.
作者信息
Simon Matthew, Yang Jiping, Gigas Jonathan, Earley Eric J, Hillpot Eric, Zhang Lei, Zagorulya Maria, Tombline Greg, Gilbert Michael, Yuen Samantha L, Pope Alexis, Van Meter Michael, Emmrich Stephan, Firsanov Denis, Athreya Advait, Biashad Seyed Ali, Han Jeehae, Ryu Seungjin, Tare Archana, Zhu Yizhou, Hudgins Adam, Atzmon Gil, Barzilai Nir, Wolfe Aaron, Moody Kelsey, Garcia Benjamin A, Robbins Paul D, Vijg Jan, Seluanov Andrei, Suh Yousin, Gorbunova Vera
出版信息
EMBO J. 2023 Feb 1;42(3):e113326. doi: 10.15252/embj.2022113326.
Abstract
摘要
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A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A.一种罕见的人类SIRT6百岁老人变体可增强基因组稳定性并促进与核纤层蛋白A的相互作用。
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