From the Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Florida, Jacksonville, FL.
Clin Nucl Med. 2023 Mar 1;48(3):233-236. doi: 10.1097/RLU.0000000000004520. Epub 2023 Jan 10.
Brown fat activation with increased radiotracer localization on FDG PET/CT studies is a well-known phenomenon. Activated brown adipose tissue (BAT) is usually seen in the supraclavicular region, but also in paraspinal and rarely in upper abdominal fat. Ours is a unique case of atypically intense, multilobular FDG uptake in activated BAT. Chart review revealed that the patient was receiving mirabegron, a known activator of brown fat. Methods of reducing brown fat uptake are known, but little information is reported on pharmacologic causes of increased uptake. Factors increasing FDG uptake in BAT should also be considered when interpreting PET/CT studies.
FDG PET/CT 研究中放射性示踪剂定位增加导致棕色脂肪激活是一种众所周知的现象。激活的棕色脂肪组织（BAT）通常可见于锁骨上区域，但也可见于椎旁区域，偶尔可见于上腹部脂肪。我们的病例为一例独特的、非典型的、多叶状激活 BAT 中出现的异常强烈的 FDG 摄取。图表回顾显示，该患者正在接受米拉贝隆治疗，这是一种已知的棕色脂肪激活剂。减少棕色脂肪摄取的方法是已知的，但关于摄取增加的药物原因的报道很少。在解释 PET/CT 研究时，也应考虑到增加 BAT 中 FDG 摄取的因素。
