Biology Centre of the Czech Academy of Sciences, Institute of Entomology, České Budějovice, Czech Republic.
Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
Mol Ecol. 2023 May;32(9):2134-2143. doi: 10.1111/mec.16870. Epub 2023 Feb 10.
Three widely accepted assumptions are based on telomere research in human cells: (i) telomere length is a determinant of replicative ageing; (ii) telomerase activity in somatic cells supports the proliferative capacity of the cells and thus contributes to their regenerative potential and is a determinant of organismal lifespan; and (iii) the lack of telomerase activity acts as a tumour suppression mechanism. However, from a broader view, the link between telomere biology and cellular and organismal ageing, as well as tumour development, remains of debate, as I demonstrate with numerous examples of invertebrate and vertebrate species. Consequently, I propose a novel hypothesis that telomere biology, via somatic telomerase activity, reflects ageing rate from the perspective of species reproduction strategy.
基于人类细胞中端粒研究，有三个被广泛认可的假设：（i）端粒长度是复制性衰老的决定因素；（ii）体细胞中的端粒酶活性支持细胞的增殖能力，从而有助于其再生潜力，并且是生物体寿命的决定因素；（iii）缺乏端粒酶活性是一种肿瘤抑制机制。然而，从更广泛的角度来看，端粒生物学与细胞和生物体衰老以及肿瘤发展之间的联系仍然存在争议，我通过大量无脊椎动物和脊椎动物物种的例子证明了这一点。因此，我提出了一个新的假设，即端粒生物学通过体细胞端粒酶活性，从物种繁殖策略的角度反映衰老速度。
