Applied Sport, Technology, Exercise and Medicine Research Centre, Swansea University, Swansea, United Kingdom.
Copenhagen University Hospital-Steno Diabetes Center Copenhagen, Herlev, Denmark.
Diabetes Technol Ther. 2023 Apr;25(4):287-292. doi: 10.1089/dia.2022.0542. Epub 2023 Feb 16.
In an in-patient switch study, 10 adults with type 1 diabetes (T1D) performed 45 min of moderate-intensity exercise on 2 occasions: (1) when using their usual insulin pump (UP) and (2) after transitioning to automated insulin delivery (AID) treatment (MiniMed™ 780G). Consensus glucose management guidelines for performing exercise were applied. Plasma glucose concentrations measured over a 3-h monitoring period were stratified into time below range (TBR, <3.9 mmol/L), time in range (TIR, 3.9-10.0 mmol/L), and time above range (TAR, >10.0 mmol/L). Overall, TBR (UP: 11 ± 21 vs. AID: 3% ± 10%, = 0.413), TIR (UP: 53 ± 27 vs. AID: 66% ± 39%, = 0.320), and TAR (UP: 37 ± 34 vs. AID: 31% ± 41%, = 0.604) were similar between arms. A proportionately low number of people experienced exercise-induced hypoglycemia (UP: = 2 vs. AID: = 1, = 1.00). In conclusion, switching to AID therapy did not alter patterns of glycemia around sustained moderate-intensity exercise in adults with T1D. Clinical Trial Registration number: NCT05133765.
在一项住院转换研究中，10 名 1 型糖尿病（T1D）成年人在两种情况下进行了 45 分钟的中等强度运动：（1）使用他们常用的胰岛素泵（UP），（2）转换为自动化胰岛素输送（AID）治疗（MiniMed™ 780G）。应用了进行运动的共识血糖管理指南。在 3 小时监测期间测量的血浆葡萄糖浓度分为以下几个时间段：（1）血糖低于目标范围（TBR，<3.9mmol/L），（2）血糖在目标范围内（TIR，3.9-10.0mmol/L），（3）血糖高于目标范围（TAR，>10.0mmol/L）。总体而言，TBR（UP：11±21%比 AID：3%±10%， = 0.413）、TIR（UP：53±27%比 AID：66%±39%， = 0.320）和 TAR（UP：37±34%比 AID：31%±41%， = 0.604）在两种治疗方式之间相似。低血糖发生的比例相对较低（UP： = 2 比 AID： = 1， = 1.00）。总之，转换为 AID 治疗并没有改变 1 型糖尿病成年人持续进行中等强度运动时的血糖模式。临床试验注册号：NCT05133765。
