Yang Yong-Chang, Shi Yi, Duobujie Jimei, Liu Xiu-Xiu, Huang Yu, Wu Yu-Bin
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Pediatrics, Naqu People's Hospital, Naqu, China.
J Obstet Gynaecol. 2023 Dec;43(1):2173563. doi: 10.1080/01443615.2023.2173563.
In high-altitude regions, low birth weight is mainly caused by hypoxia. We aimed to determine whether maternal serum uric acid (SUC) level was associated with decreased foetal birth weight. The relevant data of individual pregnant women who delivered between 37 and 40 weeks in the People's Hospital of Naqu City, Tibet were retrospectively collected. The correlation between maternal SUC and birth weight was examined using multivariate linear regression analysis and subgroup analysis. The results showed that there was a significant negative correlation between SUC and birth weight in pregnant women with proteinuria, female foetuses, and primiparas. Fitting smoothing curve analysis showed that there was a negative linear correlation between SUC and birth weight in primiparas and female foetuses. Maternal SUC is negatively associated with foetal birth weight in a single pregnancy with proteinuria, primipara, or female foetuses in the Naqu region of Tibet, China.IMPACT STATEMENT Preeclampsia associated with hyperuricaemia can affect foetal birth weight, foetal birth weight in plains area is negatively correlated with maternal hyperuricaemia. Maternal SUC was negatively correlated with foetal birth weight, especially in primipara, mothers with proteinuria, and pregnant girls. The results suggest that attention should be paid to SUC in pregnant women, especially in primipara, mothers with proteinuria, and pregnant girls, in the prevention of low birth weight infants in Naqu Plateau area of Tibet.
在高海拔地区，低出生体重主要由缺氧引起。我们旨在确定孕妇血清尿酸（SUC）水平是否与胎儿出生体重降低有关。回顾性收集了西藏那曲市人民医院37至40周分娩的个体孕妇的相关数据。采用多元线性回归分析和亚组分析检验孕妇SUC与出生体重之间的相关性。结果显示，在患有蛋白尿的孕妇、女胎和初产妇中，SUC与出生体重之间存在显著负相关。拟合平滑曲线分析显示，初产妇和女胎的SUC与出生体重之间存在负线性相关。在中国西藏那曲地区，单胎妊娠且患有蛋白尿、初产妇或女胎的孕妇中，孕妇SUC与胎儿出生体重呈负相关。影响声明：与高尿酸血症相关的子痫前期可影响胎儿出生体重，平原地区的胎儿出生体重与孕妇高尿酸血症呈负相关。孕妇SUC与胎儿出生体重呈负相关，尤其是初产妇、患有蛋白尿的母亲和怀孕女孩。结果表明，在西藏那曲高原地区预防低出生体重儿方面，应关注孕妇尤其是初产妇、患有蛋白尿的母亲和怀孕女孩的SUC。
