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处于体内电神经刺激时代开端的人类。

Humans at the dawn of the in-body electrical nerve stimulation era.

作者信息

Possover M

出版信息

Facts Views Vis Obgyn. 2022 Dec;14(4):293-298. doi: 10.52054/FVVO.14.4.041.

Abstract

BACKGROUND

The neuroprosthesis laparoscopic implantation technique for electric pelvic nerve stimulation was introduced to gynaecology over 15 years ago to treat intractable pelvic neuropathic pain. Following this first indication, other applications were developed, particularly in parapleology. The LION procedure developed to assist patients with paraplegia and common problems associated with inertia when confined to a wheelchair could find revolutionary applications in aging medicine and prevention.

MATERIALS AND METHODS

Spinal cord injured patients who have undergone the Possover's LION procedure.

MAIN OUTCOME MEASURE

PubMed was systematically searched to identify peer-reviewed articles published in English that reported on LION procedure.

RESULTS

Three independent studies published recently (100 patients worldwide) have shown revolutionary recovery of supra-spinal control in patients with chronic spinal cord injury following pelvic nerves stimulation, with 70% of them establishing a walker/crutches-assisted gait. The same studies have also shown significant whole-body muscle-mass building, peripheral vasodilatation, and an unexpected improvement in bone mineral density.

CONCLUSION

These ground-breaking findings could find revolutionary applications in aging medicine and the prevention of osteoporosis, with a huge impact on global public health. Humanity is on the cusp of an exciting new era following the introduction of the in-body electrical nerve stimulation technique.

WHAT IS NEW?: In-body electrical nerve stimulation for recovery and/or control of human peripheral somatic and autonomic nervous systems.

摘要

背景

15 多年前,用于电刺激盆腔神经的神经假体腹腔镜植入技术被引入妇科,以治疗顽固性盆腔神经性疼痛。在这一最初适应症之后,又开发了其他应用,特别是在截瘫学方面。为帮助截瘫患者以及解决长期坐在轮椅上带来的惯性相关常见问题而研发的 LION 手术,可能在老年医学和预防领域找到革命性的应用。

材料与方法

接受了波索弗 LION 手术的脊髓损伤患者。

主要观察指标

系统检索 PubMed,以识别用英文发表的、报道 LION 手术的同行评议文章。

结果

最近发表的三项独立研究(全球共 100 名患者)表明,慢性脊髓损伤患者在接受盆腔神经刺激后,脊髓上控制功能有革命性的恢复,其中 70% 的患者能够借助助行器/拐杖行走。同样的研究还显示,全身肌肉量显著增加、外周血管扩张,以及骨矿物质密度意外改善。

结论

这些开创性的发现可能在老年医学和骨质疏松症预防方面找到革命性的应用,对全球公共卫生产生巨大影响。随着体内电神经刺激技术的引入,人类正处在一个令人兴奋的新时代的开端。

新进展

用于恢复和/或控制人类外周躯体和自主神经系统的体内电神经刺激。

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Spinal cord repair: advances in biology and technology.脊髓修复:生物学和技术的进步。
Nat Med. 2019 Jun;25(6):898-908. doi: 10.1038/s41591-019-0475-6. Epub 2019 Jun 3.

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