三刺鲎（Tachypleus tridentatus）体内一种新的镉解毒途径：一种 4.3 亿年前的生物。
A novel cadmium detoxification pathway in Tri-spine horseshoe crab (Tachypleus tridentatus): A 430-million-years-ago organism.
机构信息
Guangdong Provincial Key Laboratory of Fishery Ecology and Environment, South China Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Guangzhou 510300, China; College of Fisheries Science and Life Science of Shanghai Ocean University, Shanghai 201306, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Sanya Tropical Fisheries Research Institute, Sanya 570203, China.
Guangdong Provincial Key Laboratory of Fishery Ecology and Environment, South China Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Guangzhou 510300, China; College of Fisheries Science and Life Science of Shanghai Ocean University, Shanghai 201306, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China; Sanya Tropical Fisheries Research Institute, Sanya 570203, China.
出版信息
Ecotoxicol Environ Saf. 2023 Mar 1;252:114585. doi: 10.1016/j.ecoenv.2023.114585. Epub 2023 Jan 30.
Marine and intertidal heavy metal pollution has been a major concern in recent years. Tachypleus tridentatus has existed on earth for more than 430 million years. It has suffered a sharp decline in population numbers caused by environmental pollution and anthropogenic disturbance for almost 40 years. However, the effects of heavy metal pollution on juvenile T. tridentatus have not been reported. Here we show the mechanism of cadmium (Cd) detoxification in juvenile T. tridentatus using integrated antioxidant indexes and transcriptomic and metabolomic analysis. High Cd concentration caused oxidative stress in juvenile T. tridentatus. The hazards increase with increasing Cd concentration in juvenile T. tridentatus. Transcriptomics and metabolomics analyses concluded that high Cd concentration resulted in the imbalance of glycerophospholipid metabolism in juvenile T. tridentatus to detoxify Cd. Our results offer a rationale for protective measures and further studies of heavy metal stress in T. tridentatus.
近年来，海洋和潮间带重金属污染一直是人们关注的主要问题。三疣梭子蟹在地球上已经存在了超过 4.3 亿年。由于近 40 年来环境污染和人为干扰，其种群数量急剧下降。然而，重金属污染对幼年三疣梭子蟹的影响尚未有报道。在这里，我们使用综合抗氧化指标以及转录组学和代谢组学分析，研究了重金属镉（Cd）在幼年三疣梭子蟹体内的解毒机制。高浓度的 Cd 会导致幼年三疣梭子蟹产生氧化应激。随着 Cd 浓度的增加，其危害也会增加。转录组学和代谢组学分析得出结论，高浓度的 Cd 导致幼年三疣梭子蟹甘油磷脂代谢失衡，从而起到解毒 Cd 的作用。我们的研究结果为保护措施和进一步研究三疣梭子蟹重金属胁迫提供了依据。
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