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眼部结核伴结膜肉芽肿。

Ocular tuberculosis presenting with a conjunctival granuloma.

机构信息

Service d'ophtalmologie, CHU de Fattouma-Bourguiba, faculté de médecine, université de Monastir, 5019 Monastir, Tunisia; Faculté de médecine, université de Monastir, Monastir, Tunisia.

Service d'ophtalmologie, CHU de Fattouma-Bourguiba, faculté de médecine, université de Monastir, 5019 Monastir, Tunisia.

出版信息

J Fr Ophtalmol. 2023 Mar;46(3):231-234. doi: 10.1016/j.jfo.2022.07.013. Epub 2023 Jan 30.

Abstract

An 18-year-old female patient was referred with complaints of tearing and redness in the left eye for 3 months after a mild ocular trauma with a turkey feather. She was treated with topical antibiotics and corticosteroids with no improvement. Slit-lamp examination of the left eye showed a vascularized lesion with a polypoidal appearance due to multiple contiguous micronodules on the temporal and inferior bulbar conjunctiva. Results of the anterior and posterior segment examination were unremarkable in both eyes. A biopsy specimen of the conjunctival mass showed multiple tuberculoid granulomas composed of epithelioid histiocytes with associated Langhan's type multinucleate giant cells and a necrotic nodule surrounded by histiocytes and giant cells. The Mantoux test was positive with induration of 15mm. The patient was prescribed antituberculosis therapy. Three months after treatment initiation, the conjunctival lesions had resolved. Mycobacterium tuberculosis should be considered in cases of unilateral chronic recalcitrant conjunctivitis. Biopsy of a conjunctival mass is of utmost importance to establish a definite diagnosis.

摘要

一位 18 岁女性患者左眼在轻微眼外伤后 3 个月出现流泪和眼红,眼外伤由火鸡羽毛引起。患者曾接受局部抗生素和皮质类固醇治疗,但无改善。左眼裂隙灯检查显示血管化病变,由于颞侧和下穹窿球结膜上多个连续的微小结节,呈息肉样外观。双眼眼前节和后节检查结果无明显异常。结膜肿块的活检标本显示多个结核样肉芽肿,由上皮样组织细胞组成,伴有朗格汉斯多核巨细胞,以及由组织细胞和巨细胞包围的坏死结节。结核菌素试验阳性,硬结 15mm。患者开始接受抗结核治疗。治疗开始后 3 个月,结膜病变已消退。单侧慢性难治性结膜炎应考虑结核分枝杆菌感染。结膜肿块活检对于明确诊断至关重要。

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