T-2毒素诱导大鼠肝脏和血清酶的变化。

T-2 toxin induced changes in liver and serum enzymes of rats.

作者信息

Suneja S K, Wagle D S, Ram G C

机构信息

Department of Chemistry and Biochemistry, Haryana Agricultural University, India.

出版信息

Toxicon. 1987;25(7):793-6. doi: 10.1016/0041-0101(87)90130-9.

DOI:10.1016/0041-0101(87)90130-9

PMID:3672548

Abstract

The effects on liver and serum enzymes of feeding a single dose (2 mg/kg) and daily doses (0.75 mg/kg) of T-2 toxin were studied in young male rats. Sample times were 8, 16 and 24 hr for single dose administration and 7, 14 and 21 days for daily dose administration. T-2 toxin in single and daily doses significantly reduced activities of hepatic glutamate pyruvate transaminase (GPT) and alkaline and acid phosphatases at all the sampling periods. In both feeding trials, levels of serum GPT increased, while that of acid and alkaline phosphatases significantly decreased at all the sampling times. This study indicates that the liver is affected by feeding T-2 toxin to rats.

摘要

研究了给年轻雄性大鼠单次投喂剂量（2毫克/千克）和每日投喂剂量（0.75毫克/千克）的T-2毒素对肝脏和血清酶的影响。单次给药的采样时间为8、16和24小时，每日给药的采样时间为7、14和21天。单次和每日剂量的T-2毒素在所有采样期均显著降低了肝脏谷丙转氨酶（GPT）以及碱性和酸性磷酸酶的活性。在两项投喂试验中，血清GPT水平均升高，而酸性和碱性磷酸酶水平在所有采样时间均显著降低。本研究表明，给大鼠投喂T-2毒素会对肝脏产生影响。