性别对头孢噻肟和去乙酰头孢噻肟处置的影响。

Influence of gender on the disposition of cefotaxime and desacetylcefotaxime.

作者信息

Guay D R, Matzke G R, Heim K L, Halstenson C E, Abraham P A, Keane W F

机构信息

Drug Evaluation Unit, Hennepin County Medical Center, Minneapolis, Minnesota 55415.

出版信息

Ther Drug Monit. 1987 Sep;9(3):259-62. doi: 10.1097/00007691-198709000-00002.

DOI:10.1097/00007691-198709000-00002

PMID:3672567

Abstract

The pharmacokinetics of cefotaxime and desacetylcefotaxime were evaluated in 11 female and 13 male subjects with end-stage renal disease. Subjects received single 1- or 2-g intravenous doses of cefotaxime sodium. Serum, urine, and dialysate concentrations of cefotaxime and desacetylcefotaxime were determined using high performance liquid chromatography. The results indicate that gender has no clinically significant influence on the disposition of cefotaxime or its active metabolite desacetylcefotaxime.

摘要

在11名女性和13名男性终末期肾病患者中评估了头孢噻肟和去乙酰头孢噻肟的药代动力学。受试者接受了单次1克或2克静脉注射剂量的头孢噻肟钠。使用高效液相色谱法测定头孢噻肟和去乙酰头孢噻肟的血清、尿液和透析液浓度。结果表明，性别对头孢噻肟或其活性代谢物去乙酰头孢噻肟的处置没有临床显著影响。