Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Eur J Neurosci. 2023 Mar;57(6):900-917. doi: 10.1111/ejn.15926. Epub 2023 Feb 16.
The bed nuclei of the stria terminalis (BST) is recognised as a pivotal integrative centre for monitoring emotional valence. It is implicated in the regulation of diverse affective states and motivated behaviours, and decades of research have firmly established its critical role in anxiety-related behavioural processes. Researchers have recently intricately dissected the BST's dynamic activities, its connection patterns and its functions with respect to specific cell types using multiple techniques such as optogenetics, in vivo calcium imaging and transgenic tools to unmask the complex circuitry mechanisms that underlie anxiety. In this review, we principally focus on studies of anxiety-involved neuromodulators within the BST and provide a comprehensive architecture of the anxiety network-highlighting the BST as a key hub in orchestrating anxiety-like behaviour. We posit that these promising efforts will contribute to the identification of an accurate roadmap for future treatment of anxiety disorders.
终纹床核（BST）被认为是监测情绪效价的关键整合中心。它与多种情感状态和动机行为的调节有关，几十年来的研究已经明确确立了其在与焦虑相关的行为过程中的关键作用。研究人员最近使用多种技术，如光遗传学、体内钙成像和转基因工具，对 BST 的动态活动、连接模式及其与特定细胞类型的功能进行了精细剖析，以揭示焦虑相关的复杂电路机制。在这篇综述中，我们主要关注 BST 中涉及焦虑的神经调节剂的研究，并提供焦虑网络的综合架构，突出 BST 作为协调类似焦虑行为的关键枢纽。我们认为，这些有希望的努力将有助于确定未来治疗焦虑障碍的准确路线图。
