Boskabadi Seyyed Javad, Ramezaninejad Sima, Sohrab Masoumeh, Farhadi Roya
Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Neonatology, Pediatrics Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Clin Med Insights Case Rep. 2023 Jan 26;16:11795476231151330. doi: 10.1177/11795476231151330. eCollection 2023.
Diazoxide is one of the FDA-approved pharmacologic treatments for hyperinsulinemic hypoglycemia, however, its adverse effects in infants are not well described. We reported a 37-week-old boy with the diagnosis of hypoglycemia. We started a dextrose infusion, but we used oral diazoxide, due to hypoglycemia episodes despite the increase in dextrose intake. The newborn had a normoglycemic condition after gradually increasing the diazoxide dose to 15 mg/kg/day. He was fully breastfed and discharged at 14 days of age with ongoing diazoxide. In weekly serial clinical follow-ups, the parents noticed an increase in the growth of forehead and facial hair that was diagnosed as diazoxide-induced hypertrichosis. Diazoxide was gradually tapered, and hypertrichosis continued until 1 month after dioxide discontinuation. Diazoxide use in NICU settings has increased over time. Diazoxide has many side effects, one of which is hypertrichosis. Many diazoxide side effects have been reported in adults or children and few studies have reported the prevalence of these adverse effects of diazoxide in neonates and infants.
二氮嗪是美国食品药品监督管理局（FDA）批准用于治疗高胰岛素血症性低血糖症的药物之一，然而，其在婴儿中的不良反应尚未得到充分描述。我们报告了一名37周大被诊断为低血糖症的男婴。我们开始进行葡萄糖输注，但由于尽管葡萄糖摄入量增加仍有低血糖发作，我们使用了口服二氮嗪。在将二氮嗪剂量逐渐增加至15mg/kg/天后，新生儿血糖恢复正常。他完全母乳喂养，14日龄时在持续服用二氮嗪的情况下出院。在每周的系列临床随访中，父母注意到前额和面部毛发增多，被诊断为二氮嗪引起的多毛症。二氮嗪逐渐减量，多毛症持续到二氮嗪停用后1个月。随着时间的推移，新生儿重症监护病房（NICU）中二氮嗪的使用有所增加。二氮嗪有许多副作用，其中之一就是多毛症。成人或儿童中已报道了许多二氮嗪的副作用，很少有研究报道二氮嗪这些不良反应在新生儿和婴儿中的发生率。
