Liver-specific deficiency of TMEM30A develops spontaneous hepatocellular carcinoma.
作者信息
Liu Leiming, Xia Zhiqing, Zhang Yongming, Su Jingjing, Sun Leimin, Zhang Lingling
机构信息
International Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, P. R. China.
Laboratory of Applied Pharmacology and Department of Pharmacology, College of Pharmacy, Weifang Medical University, Weifang, Shandong, P. R. China.
出版信息
Gastroenterol Rep (Oxf). 2023 Jan 25;11:goad003. doi: 10.1093/gastro/goad003. eCollection 2023.
Abstract
摘要
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Deletion of a flippase subunit in hematopoietic cells impairs mouse fetal liver erythropoiesis.造血细胞中翻转酶亚基的缺失可损害小鼠胎肝红细胞生成。
Haematologica. 2019 Oct;104(10):1984-1994. doi: 10.3324/haematol.2018.203992. Epub 2019 Feb 28.
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Am J Pathol. 2017 Dec;187(12):2775-2787. doi: 10.1016/j.ajpath.2017.08.011. Epub 2017 Sep 15.
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Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.半胱氨酸天冬氨酸蛋白酶介导热激磷脂翻转酶的切割导致凋亡时磷脂酰丝氨酸暴露。
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Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.肠道微生物群和 TLR4 促进肝细胞癌的发生。
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CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells.CDC50A 在人类癌细胞摄取抗癌药物帕比司他中发挥关键作用。
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NF-kappaB functions as a tumour promoter in inflammation-associated cancer.核因子-κB在炎症相关癌症中作为肿瘤促进因子发挥作用。
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